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TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsRNAseq of follicular lymphoma patient samples treated with anti-IgM, DC-SIGN or an isotype control
Here we investigate the relevance of the microenvironment in follicular lymphoma by studying the effect of the lectin DC-SIGN, expressed by macrophages on B-cell receptor activation. We compare the effect of DC-SIGN and anti-IgM stimulation on FL by treating 3 FL samples with 20 μg/ml of goat F(ab’)...
ORGANISM(S): Homo sapiens 
2020-01-31 | E-MTAB-8708 | biostudies-arrayexpress
GenomicsDC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion
DC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion
PRJNA1104132 | ENA
GenomicsRNAseq of follicular lymphoma patient samples treated with anti-IgM, DC-SIGN or an isotype control
RNAseq of follicular lymphoma patient samples treated with anti-IgM, DC-SIGN or an isotype control
PRJEB36346 | ENA
TranscriptomicsDC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion
The modulation of immune responses by innate immune receptors plays a pivotal role in the progression of non-alcoholic steatohepatitis (NASH). In this study, we aim to comprehensively dissect the involvement of the C-type lectin receptor DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) in NASH progr...
ORGANISM(S): Mus musculus 
2026-04-22 | GSE264747 | GEO
TranscriptomicsIdentification of miR-181a target mRNAs by RIP-CHIP during terminal differentiation of DC-SIGN+ mo-DCs
DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a micro-RNA, miR-181a, and a molecular mechanism that simult...
ORGANISM(S): Homo sapiens 
2020-03-10 | GSE96847 | GEO
TranscriptomicsDC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2007-04-24 | GSE6090 | GEO
UnknownDC-SIGN Family of Receptors
Not available
S-EPMC7122914 | biostudies-literature
UnknownNon-carbohydrate inhibitors of the lectin DC-SIGN.
Not available
S-EPMC2546503 | biostudies-literature
UnknownAutonomous tetramerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR.
Not available
S-EPMC2680971 | biostudies-literature
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