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TranscriptomicsMicroarray analyses of lymph node dendritic cells (DCs) stimulated in vitro with papain or LPS
T helper type 2 (Th2) responses are induced by protease allergens and helminthes. However the molecular mechanisms that initiate Th2 responses are poorly understood. To obtain insight into this mechanism, we performed a microarray analysis of lymph node DCs stimulated in vitro with the protease alle...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-21602 | biostudies-arrayexpress
TranscriptomicsGenomic expression analysis of human monocyte-derived DCs and monocytes
To identify the functional non-coding RNAs in human DC development, we explored the gene expression profiles during DC development from peripheral monocytes. Using RNA-seq, we identified many annotated lncRNAs with markedly altered expressions during human DC differentiation and maturation. RNA samp...
ORGANISM(S): Homo sapiens 
2014-05-02 | E-GEOD-54401 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BDC2.5 CD4T cells isolated from NOD mice after in vivo antigen stimulation with either DEC205+ or DCIR2+ DCs.
We identified DCIR2+DCs but not DEC205+DCs as able to induce peripheral T cell tolerance in pre-diabetic autoimmune NOD mice. To determine what distinct genetic programs are elicited in the auto-reactive CD4 T cells early after stimulation by these two DC subsets, we utilized adoptive transfer of BD...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69554 | biostudies-arrayexpress
TranscriptomicsGene expression on in vitro activated DCs
We have analyzed the effects of IL-27 signaling in dendritic cells (DCs) in the activation and polarization of effector and regulatory T cells, and the development of experimental autoimmune encephalomyelitis, an experimental model of multiple sclerosis. In this dataset, we include the results of tr...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-49328 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of monocyte-derives DCs stimulated with various compounds
Little is known about the early transcriptional events in innate immune signaling in immature and tolerogenic monocyte-derived dendritic cells (DCs), the professional antigen-presenting cells of our immune system. TLR ligands usually induce a proinflammatory transcriptional response, whereas IL10 an...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-23371 | biostudies-arrayexpress
TranscriptomicsFunctional modulation of dendritic cells (DCs) by photo-switchable generation of intracellular ROS
This experiment was performed to estimate the difference between DCs stimulated with intracellular ROS or LPS. Total RNA obtainded from DCs stimulated with intracellular ROS or LPS was analyzed for transcriptome
ORGANISM(S): Mus musculus 
2012-11-24 | E-GEOD-42476 | biostudies-arrayexpress
TranscriptomicsTranscriptome of inflammatory myeloid DCs in psoriasis
Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major 'inflammatory' dermal DC population in psoriasis vulgaris and CD1c+ DCs as the 'resident' cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populatio...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20264 | biostudies-arrayexpress
TranscriptomicsExpression data from NOD and C57BL/6 mouse pancreas CD8α- Dendritic Cells (DCs) under steady-state and after in-vitro LPS stimulation
Abstract Two major dendritic cell (DC) subsets have been described in the islets of mice: The immunogenic CD8α-CD11b+ DCs and the tolerogenic CD8α+CD103+ DCs. We have recently reported on reduced numbers of the minor population of tolerogenic CD8α+CD103+ DCs in the pancreas of 5 week old pre-dia...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-45028 | biostudies-arrayexpress
TranscriptomicsDistinct murine mucosal Langerhans cell subsets develop from pre-DCs and monocytes
Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. In contrast to skin LCs originating from self-renewing radioresistant embryonic precursors, we found that oral mucosal LCs derive from circulating radiosensitive precursors...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-68789 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for colonic lamina propria DCs of CD300a deficient mice
To further development of our gene expression approach to CD300a deficiency on dendritic cells (DCs) in colonic lamina propria, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish CD300a deficiency on DCs in coloni...
ORGANISM(S): Mus musculus 
2015-04-10 | E-GEOD-67696 | biostudies-arrayexpress
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