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ProteomicsIn vivo DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008546 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
ProteomicsIn vitro DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approv...
ORGANISM(S): Homo sapiens (Human) 
2018-01-31 | PXD008582 | Pride
Signalling Metastatic colorectal cancer Ddr1 tyrosine kinase 
GenomicTyrosine Kinase Mutations in Endometrial Cancer

The purpose of the original study was to search for somatic mutations in the tyrosine kinome of serous and clear cell endometrial carcinomas (human). The study was conducted in two phases.

Phase 1: A mutation discovery screen, in which ~577 exons encoding the catalytic domains of 86 tyrosi...

phs000841 | dbGaP
UnknownAnticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1.
Not available
S-EPMC4794364 | biostudies-literature
TranscriptomicsInteractions between Jag1 and Ddr1 in mouse liver
Microarray gene expression experiments to identify differentially expressed genes and pathways in Jag1 conditional/null livers reveal up-regulation of many genes related to fibrosis and ECM interactions. 3 Jag1 conditional/null mutant mice versus 3 littermate wildtype control mice.
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-46577 | biostudies-arrayexpress
TranscriptomicsDDR1 knockdown in BXPC3 cell line
Examination of effect of stable DDR1 knockdown by shRNA on transcriptional profile in BXPC3 cell line to understand role of DDR1 in tumorigenesis. Transcriptional profiles of parental BXPC3 cell line was compared to BXPC3 cells stably transfected with non-target shRNA or DDR1 shRNA, N=3 for each con...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-39207 | biostudies-arrayexpress
UnknownDiscoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
Not available
S-EPMC10567009 | biostudies-literature
TranscriptomicsUbiquitin specific peptidase 7 promotes TP53 mutant malignancy by deubiquitinating and stabilizing DDR1
Receptor tyrosine kinase DDR1 (Discoidin Domain Receptor 1) interacts with the extracellular matrix (ECM) to promote tumor cell proliferation through its intracellular kinase activity, while its extracellular non-enzymatic domain creates a physical barrier for immune evasion. Although DDR1 inhibitor...
ORGANISM(S): Homo sapiens 
2025-09-03 | GSE301195 | GEO
GenomicsUbiquitin specific peptidase 7 promotes TP53 mutant malignancy by deubiquitinating and stabilizing DDR1
Ubiquitin specific peptidase 7 promotes TP53 mutant malignancy by deubiquitinating and stabilizing DDR1
PRJNA1284252 | ENA
UnknownDiscoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease.
Not available
S-EPMC6602183 | biostudies-literature
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