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UnknownCytogenetic prognostication within medulloblastoma subgroups.

Purpose

Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differ...
S-EPMC3948094 | biostudies-literature
TranscriptomicsmRNA expression data from primary untreated neuroblastoma tumour samples
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains largely elusive. Here we examined the effects of activation of the entire miR-17-92 cluster on global protein expression in neuroblastoma cells. In this dataset we deposit global mRNA expressio...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-21713 | biostudies-arrayexpress
TranscriptomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication
RNA-seq of human cells Edited using CRISPR vs parental and Unedited control. We identified a rare homozygous intronic variant in the ATP2B1 locus (rs111337717; chr12:89643729, T>C) that is associated with the severity of COVID-19 (i.e., symptomatic versus asymptomatic patients). Next, we employed ...
ORGANISM(S): Homo sapiens 
2024-05-13 | E-MTAB-13916 | biostudies-arrayexpress
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