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TranscriptomicsIn vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-60388 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsGene expression in the mitochondrial syndrome of coenzyme Q deficiency
Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse est...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-33940 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
TranscriptomicsRNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels
The mammalian RNA-binding protein AUF1 (AU-binding factor 1, also known as heterogeneous nuclear ribonucleoprotein D, hnRNP D) binds to numerous mRNAs and influences their post-transcriptional fate. Given that many AUF1 target mRNAs encode muscle-specific factors, we investigated the function of AU...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-58259 | biostudies-arrayexpress
TranscriptomicsComparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle [Human]
With the population of older and overweight individuals on the rise in the Western world, there is an ever greater need to slow the aging processes and reduce the burden of age-associated chronic disease that would significantly improve the quality of human life and reduce economic costs. Caloric re...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-38012 | biostudies-arrayexpress
TranscriptomicsComparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle [Rat]
With the population of older and overweight individuals on the rise in the Western world, there is an ever greater need to slow the aging processes and reduce the burden of age-associated chronic disease that would significantly improve the quality of human life and reduce economic costs. Caloric re...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-38062 | biostudies-arrayexpress
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