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TranscriptomicsGene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib
Relapsed/refractory Hodgkin lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65483 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with perifosine in combination with sorafenib
Three HL cell lines (HD-MyZ, L-540 and HDLM-2) were used to investigate the effects of perifosine and sorafenib using in vitro assays analyzing cell growth, cell cycle distribution, gene expression profiling (GEP), and apoptosis. Western blotting (WB) experiments were performed to determine whether ...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-31059 | biostudies-arrayexpress
TranscriptomicsAberrant choline metabolism in epithelial ovarian cancer: relevance of choline kinase activity and expression
Detection of the abnormal phosphatidylcholine (PtdCho) metabolism in EOC by analysis of magnetic resonance profile (MRS), showed a significant increase of PCho content in EOC cells as compared with non tumoral counterparts associated with activation of choline kinase (ChoK), the enzyme responsible f...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-39943 | biostudies-arrayexpress
TranscriptomicsmicroRNA alterations associated to early relapse in advanced stage ovarian cancer patients (validation set)
A set of 45 surgical specimens has been profiled for miRNA expression to validate miRNA alterations associated to early relapse in advanced stage ovarian cancer patients. Fresh frozen samples were collected from a series of consecutive patients with high-grade advanced stage ovarian cancer who under...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-67819 | biostudies-arrayexpress
TranscriptomicsRPF-1 transcription factor coordinates expression of developmental genes in inducible HEK293/RPF-1 stable transfectants
RPF-1, a transcription factors encoded by POU6F2 gene, appears to be expressed in the developing nervous system and embryonic kidney. We generated a stable HEK/RPF-1 transfectant expressing the protein in a tetracycline (Tet)-dependent induction and addressed the whole transcriptome regulated by RPF...
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-55472 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myxoid liposarcomas (validation set INT-B)
FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initially believed to be distinct diseases. Currently, myxoid and RC liposarcoma are regarded to represent the well differentiated and the poorly differentiated en...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-55465 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myxoid liposarcomas (training set INT-A)
FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initially believed to be distinct diseases. Currently, myxoid and RC liposarcoma are regarded to represent the well differentiated and the poorly differentiated en...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-55464 | biostudies-arrayexpress
TranscriptomicsComparison of microarray platforms for measuring differential microRNA expression (Agilent data)
Microarray technology applied to miRNA profiling is a promising tool in many research fields. At present, only few studies have addressed intra- and inter-platform reproducibility by using tissues/cell-lines of different origin to maximize differences in miRNA content. Although the approach might pr...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-33124 | biostudies-arrayexpress
TranscriptomicsComparison of microarray platforms for measuring differential microRNA expression (Illumina data)
Microarray technology applied to miRNA profiling is a promising tool in many research fields. At present, only few studies have addressed intra- and inter-platform reproducibility by using tissues/cell-lines of different origin to maximize differences in miRNA content. Although the approach might pr...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-33125 | biostudies-arrayexpress
TranscriptomicsComparison of microarray platforms for measuring differential microRNA expression (Miltenyi data)
Microarray technology applied to miRNA profiling is a promising tool in many research fields. At present, only few studies have addressed intra- and inter-platform reproducibility by using tissues/cell-lines of different origin to maximize differences in miRNA content. Although the approach might pr...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-33123 | biostudies-arrayexpress
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