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TranscriptomicsInteractions among Polycomb domains are guided by chromosome architecture
Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-23166 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila)
We performed a series of microarray expression profile experiments in central brain tissue from 3rd instar larvae, interrogating expression differences between wild type and In(3LR)sep strains. Since our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166), demonstrated dramatic chan...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-26693 | biostudies-arrayexpress
TranscriptomicsCHARACTERIZATION AND DYNAMICS OF MOUSE PERICENTROMERE-ASSOCIATED DOMAINS
Despite recent progress in genome topology knowledge, the role of repeats, comprising the majority of mammalian genomes, remains elusive. Satellites are highly abundant sequences that cluster around centromeres, attract pericentromeric heterochromatin and aggregate into nuclear chromocenters that ar...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-65618 | biostudies-arrayexpress
TranscriptomicsMapping of Polycomb binding in Drosophila larval brain tissue using DamID
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23298 | biostudies-arrayexpress
TranscriptomicsMapping of H3K27me3 enrichment in Drosophila larval brain tissue using ChIP-chip
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23299 | biostudies-arrayexpress
GenomicsEpigenomic annotation of gene regulatory alterations during evolution of the primate brain
While genome sequencing has identified numerous non-coding alterations between primate species, which of these are regulatory and potentially relevant to the evolution of the human brain is unclear. Here, we annotate cis-regulatory elements (CREs) in the human, rhesus macaque and chimpanzee genome u...
ORGANISM(S): Macaca mulatta 
2016-01-13 | E-GEOD-67978 | biostudies-arrayexpress
TranscriptomicsPolycomb chromatin domains in Drosophila
This SuperSeries is composed of the following subset Series: GSE23166: Interactions among Polycomb domains are guided by chromosome architecture GSE26693: Gene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila) Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2011-01-31 | E-GEOD-26694 | biostudies-arrayexpress
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