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TranscriptomicsCD34+ treatment with MicroVescicles
Transcription profiling analysis was performed on purified CD34+ cell lines (Cord Blood CD34+) treated with ExtracellularVescicles (EVs) isolated from bone marrow mesenchymal stem cells (BM-MSC).
ORGANISM(S): Homo sapiens 
2015-10-14 | E-MTAB-3576 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41972 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human multiple myloma cell lines with or without p53 mutations
The miRNA profiles were analyzed for 6 multiple myloma cell lines with or without p53 mutations, in duplicate
ORGANISM(S): Homo sapiens 
2010-07-22 | E-TABM-1037 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human multiple myloma p53 wild type cells treated with nutlin 3A
The miRNA profiles were analyzed for nutlin 3A treated and untreated multiple myloma p53 wild type cells
ORGANISM(S): Homo sapiens 
2010-07-22 | E-TABM-1038 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Expression)
Primary plasma cell leukaemia (pPCL) is a rare, yet aggressive form of de novo plasma cell tumor, distinguished from secondary PCL (sPCL) which represents a leukemic transformation of pre-existing multiple myeloma (MM). Here, we performed a comprehensive molecular analysis of a prospective series of...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-39381 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [RNA-seq]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44052 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of a prospective series of primary plasma cell leukemia revealed genes associated with tumor progression and poorest outcome
Plasma cell leukemia (PCL) is a rare form of plasma cell dyscrasia that presents either as a progression of previously diagnosed multiple myeloma (MM), namely secondary PCL (sPCL), or as the initial manifestation of disease, namely primary PCL (pPCL). Although presenting signs and symptoms include t...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39925 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [NanoString]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41971 | biostudies-arrayexpress
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