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MetabolomicsToxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The presen...
2023-10-10 | MTBLS1481 | MetaboLights
ProteomicsProteomic alterations in the context of survival signaling and redox homeostasis linked to de novo fatty acid biosynthesis
Cell death programs like apoptosis, necroptosis, and ferroptosis have an oxidative component linked to lipid metabolism that impacts membrane homeostasis. Evidence for cross-talk between these programs is emerging, highlighting the need for overarching regulatory mechanisms. We investigated changes ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-04 | PXD053866 | Pride
Programmed cell death Phospholipids Monounsaturated fatty acid Redox homeostasis Mouse fibroblast Cytotoxic stress 
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
TranscriptomicsIdentification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas
Background/Objective: MicroRNAs (miRNAs) play a pivotal role in cancerogenesis and cancer progression, but their specific role in metastasis of clear cell renal cell carcinomas (ccRCCs) as so-called metastamirs is still limited. Based on microRNA microarray analyses from normal (n=12) and cancerous ...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-37989 | biostudies-arrayexpress
TranscriptomicsATAC-seq of Mus musculus embryonic cell types in response to Pbx1 knockout
ATAC-seq was performed, mapped, and analyzed as previously described (PMID: 34446717: \\"ATAC-seq was performed on 50,000 cells per replicate as described in Buenrostro et al. (with modifications based on Corces et al.), on EpiSCs and PSM-differentiated cell populations at desired time-points. Libra...
ORGANISM(S): Mus musculus 
2023-12-01 | E-MTAB-13407 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsInstruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pa...
ORGANISM(S): Mus musculus 
2013-10-15 | E-MTAB-1820 | biostudies-arrayexpress
UnknownRisk stratification as a guide to goal-oriented management of patients with fibrotic interstitial lung disease: a registry-based analysis.
Not available
S-EPMC12813680 | biostudies-literature
TranscriptomicsTranscription profiling and proteomic profiling of mouse hippocampus
We have correlated transciptomics, proteomics and toponomics analyses of hippocampus tissue of inbred C57/BL6 mice to analyse the interrelationship of expressed genes and proteins at different levels of organization. We find that transcriptome and proteome levels of function are highly conserved bet...
ORGANISM(S): Mus musculus 
2008-06-19 | E-GEOD-8239 | biostudies-arrayexpress
ModelsMorpheus: open source modelling and simulation framework for multicellular systems
Morpheus: open source modelling and simulation framework for multicellular systems
2018-06-08 | 320 | FAIRDOMHub
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