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TranscriptomicsNovel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis
Skeletal muscle contains long multinucleated and contractile structures known as muscle fibers, which arise from the fusion of myoblasts into nucleated myotubes during myogenesis. The myogenic regulatory factor (MRF) MYF5 is the earliest to be expressed during myogenesis and functions as a transcri...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-73704 | biostudies-arrayexpress
ProteomicsSurfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
Senescent cells are beneficial for repairing acute tissue damage but are harmful when they accumulate in tissues, as occurs with advancing age. Senescence-associated extracellular vesicles (S-EVs) can mediate cell-to-cell communication and export intracellular content to the microenvironment of agi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-09 | MSV000090503 | MassIVE
TranscriptomicsExpression data from human liver cell line induced by PCB153
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases is not fully understood. The knowledge of global gene expression will help us to devlop early diagnostic biomarkers for PCB induced h...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-6494 | biostudies-arrayexpress
TranscriptomicsExpression data from human liver cell line induced by PCB77
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases is not fully understood. The knowledge of global gene expression will help us to develop early diagnostic biomarkers for PCB induced ...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-6869 | biostudies-arrayexpress
GenomicsDynamic BRG1 Recruitment During T Helper Differentiation And Activation Reveals Distal Regulatory Elements
We found binding of the remodeling protein BRG1 was programmed by lineage and activation signals. BRG1 binding was positively correlated with gene activity at protein-coding and miRNA genes. BRG1 binding was found at promoters and distal regions, including known and novel distal regulatory element...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-23719 | biostudies-arrayexpress
TranscriptomicsHuman umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes [rat]
Human and rat umbilical cord matrix mesenchymal stem cells (UCMSC) possess the ability to control the growth of breast carcinoma cells. Comparative analyses of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Their different tu...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-64838 | biostudies-arrayexpress
GenomicsGenome-wide analysis of acetylated H4K5 binding offers new insights into the acute and chronic effects of METH on gene expression in the dorsal striatum
In contrast to the acute METH-induced transcriptional changes, chronic METH administration produces differential changes in IEG responses and blunts the striatal effects of a single METH injection (McCoy et al., 2011). These observations suggested that chromic METH might have caused changes in the m...
ORGANISM(S): Rattus norvegicus 
2013-02-28 | E-GEOD-42776 | biostudies-arrayexpress
TranscriptomicsSenescence-associated lncRNAs: senescence-associated long noncoding RNAs.
Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally. Here, we sought to identify lncRNAs differentiall...
ORGANISM(S): Homo sapiens 
2016-02-08 | E-GEOD-77675 | biostudies-arrayexpress
TranscriptomicsHuman umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes [human]
Human and rat umbilical cord matrix mesenchymal stem cells (UCMSC) possess the ability to control the growth of breast carcinoma cells. Comparative analyses of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Their different tu...
ORGANISM(S): Homo sapiens 
2015-08-06 | E-GEOD-64827 | biostudies-arrayexpress
TranscriptomicsAge-related changes in microRNA levels in serum
microRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs. Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease. Although we and others have found an age-...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53439 | biostudies-arrayexpress
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