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MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-13 | MTBLS616 | MetaboLights
MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-12 | MTBLS614 | MetaboLights
TranscriptomicsAnalysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition
In pigs, adipose tissue is one of the principal organs involved in the regulation of lipid metabolism. It is particulary involved in the overall fatty acid synthesis with consequences in other lipid-target organs such as muscles and the liver. With this in mind, we have used massive, parallel high-t...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-52012 | biostudies-arrayexpress
TranscriptomicsRNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids
Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols, however total seed oil is also reduced up to 50%. Investigations into the cause of the reduced oil phenotype through in vivo [14C]acteate and [3...
ORGANISM(S): Arabidopsis thaliana 
2014-01-10 | E-GEOD-53952 | biostudies-arrayexpress
ProteomicsAregger_C12ORF49_BioID_2020_TripleTOF5600
This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on AB SCIEX 5600 TripleTOF mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Michael Aregger, affinity purification and mass spectrometric acquisition was performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085005 | MassIVE
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
TranscriptomicsGene Expression in the Human Mammary Epithelium in response to consumption of high fat (H-FAT) and high carbohdyrate (H-CHO) diets.
Mammary gland (MG) de novo lipogenesis contributes significantly to milk fat in animals but little is known in humans. We hypothesized that de novo lipogenesis, as reflected by incorporation of 13C carbons from [U-13C]glucose into fatty acids (FAs) and glycerol in triglycerides (TG), will be greate...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-51874 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis LEC1-overexpressing transgenic plants reveals LEAFY COTYLEDON1 is a key regulator of fatty acid biosynthesis in Arabidopsis thaliana
In plants, fatty acids are de novo synthesized predominantly in plastids fromacetyl-CoA. Although fatty acid biosynthesis has been biochemically well-studied, little isknown about the regulatory mechanisms of the pathway. Here, we show that overexpressionof the Arabidopsis (Arabidopsis thaliana) LEA...
ORGANISM(S): Arabidopsis thaliana 
2008-10-25 | E-GEOD-12137 | biostudies-arrayexpress
ProteomicsAlgal carbon concentrating drives fatty acid biosynthesis beyond photosynthesis
The global carbon cycle underpins Earth’s sustainability, with algae playing a pivotal role in biological carbon assimilation. Efficient photosynthetic carbon fixation in aquatic environments is facilitated by algal CO2-concentrating mechanisms (CCMs). Despite their importance, the coordination of i...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-08-22 | PXD066441 | Pride
Metabolic interaction De novo fatty acid biosynthesis Co2-concentrating mechanisms Global carbon cycle Algae Protein condensates Pyrenoid Chlamydomonas reinhardtii Photosynthetic carbon fixation 
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