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MetabolomicsLC-MS-based isotope tracing data supporting cholesterol- and EA2-regulated fatty acid synthesis and tumor metabolic remodeling
This study contains LC-MS-based stable isotope tracing data investigating cholesterol- and EA2-regulated tumor metabolic remodeling. The dataset includes U-13C-glucose tracing in tumor cells and D2O tracing in animal models, supporting analysis of cholesterol-driven metabolic remodeling and the supp...
2026-10-03 | MTBLS14937 | MetaboLights
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-13 | MTBLS616 | MetaboLights
TranscriptomicsAnalysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition
In pigs, adipose tissue is one of the principal organs involved in the regulation of lipid metabolism. It is particulary involved in the overall fatty acid synthesis with consequences in other lipid-target organs such as muscles and the liver. With this in mind, we have used massive, parallel high-t...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-52012 | biostudies-arrayexpress
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-12 | MTBLS614 | MetaboLights
TranscriptomicsRNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids
Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols, however total seed oil is also reduced up to 50%. Investigations into the cause of the reduced oil phenotype through in vivo [14C]acteate and [3...
ORGANISM(S): Arabidopsis thaliana 
2014-01-10 | E-GEOD-53952 | biostudies-arrayexpress
ProteomicsAregger_C12ORF49_BioID_2020_TripleTOF5600
This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on AB SCIEX 5600 TripleTOF mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Michael Aregger, affinity purification and mass spectrometric acquisition was performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085005 | MassIVE
GenomicsInhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis
Inhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis
PRJNA1269053 | ENA
TranscriptomicsGene Expression in the Human Mammary Epithelium in response to consumption of high fat (H-FAT) and high carbohdyrate (H-CHO) diets.
Mammary gland (MG) de novo lipogenesis contributes significantly to milk fat in animals but little is known in humans. We hypothesized that de novo lipogenesis, as reflected by incorporation of 13C carbons from [U-13C]glucose into fatty acids (FAs) and glycerol in triglycerides (TG), will be greate...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-51874 | biostudies-arrayexpress
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
TranscriptomicsInhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis
De novo fatty acid synthesis produces the acyl units needed to generate phospholipids, lipoproteins, enzyme prosthetic factors, polyketides, and mycolic acids in Mycobacterium tuberculosis (Mtb). Here, we identifed sALT629, a novel butoxyphenyl-tetrazole-acetamide compound that inhibits de novo lipi...
ORGANISM(S): Mycobacterium tuberculosis 
2025-06-02 | GSE298382 | GEO
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