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ProteomicsIFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections
Protein kinase R (PKR) expression is induced by interferons. This protein is activated by double-stranded (ds) RNAs or RNAs containing duplex regions, produced after different stimuli, such as after viral infections, leading to the phosphorylation of the eukaryotic translation initiation factor 2α (...
ORGANISM(S): Homo Sapiens (human) 
2026-10-22 | PXD086108 | JPOST Repository
ProteomicsTripartite motif-containing 34 (TRIM34) protein interacts with the nucleocytoplasmic transport machinery and negatively modulates antiviral responses
The tripartite motif-containing (TRIM) 34 protein is an interferon (IFN)-induced protein whose expression is upregulated after influenza A virus (IAV) infection. Here, we identify a previously unknown function for TRIM34 as a negative regulator of innate immune responses following IFN treatment and ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-27 | PXD086323 | Pride
Iav infection Trim34 protein (ifn)-induced protein 
TranscriptomicsSevere acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress respo...
ORGANISM(S): Chlorocebus aethiops 
2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress
TranscriptomicsThe PDZ-binding motif of SARS-CoV envelope protein is a determinant of viral pathogenesis
A recombinant SARS-CoV lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major virulence determinant in vivo. Elimination of SARS-CoV E protein PBM by using reverse genetics led to at...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-52920 | biostudies-arrayexpress
UnknownCharacterizing Emerging Canine H3 Influenza Viruses.
Not available
S-EPMC7182277 | biostudies-literature
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