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ProteomicsAutophosphorylation of the CK1 kinase domain regulates enzyme activity and substrate specificity
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe a new mechanism of CK1 regulation conserved from yeast to human – autopho...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-07-20 | PXD026766 | Pride
Casein kinase 1 Ck1 S. pombe Substrate specificity Kinase regulation 
ProteomicsCK1 promotes double-strand break repair in fission yeast
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. The C-termini of these enzymes are thought to inhibit kinase activity by acting as pseudosu...
ORGANISM(S): Schizosaccharomyces pombe 
2025-05-06 | PXD033223 | Pride
Casein kinase 1 Ck1 Kinase substrates S. pombe Kinase regulation 
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