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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
ModelsDeath Receptor Signaling
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including c...
2084 | Cell Collective
UnknownIntrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.
Not available
S-EPMC3524638 | biostudies-literature
TranscriptomicsTranscription profiling of livers of C57BL/6 mice and LDL receptor deficient mice fed on either low fat or high fat diet to study liver gene expression associated with diet.
Examination of gene expression profiles from liver of C57BL/6 mice and LDL receptor deficient mice fed on either a low fat diet or a high fat Western-style diet for 12 weeks. Three replicates of each condition analyzed. Keywords = LDL receptor deficiency, high fat diet, atherosclerosis, liver
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-363 | biostudies-arrayexpress
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-GEOD-55728 | biostudies-arrayexpress
UnknownDeath receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis.
Not available
S-EPMC3824687 | biostudies-literature
UnknownA Structural and Functional Perspective of Death Receptor 6.
Not available
S-EPMC8987162 | biostudies-literature
TranscriptomicsSurvival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3b phosphorylation
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report here a novel finding that PDGF...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-19207 | biostudies-arrayexpress
UnknownDeath Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.
Not available
S-EPMC5360522 | biostudies-literature
UnknownDual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death.
Not available
S-EPMC3064233 | biostudies-literature
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