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ProteomicsProteomic profiling of human decidual immune proteins during Toxoplasma gondii infection
A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that m...
ORGANISM(S): Homo sapiens (Human) 
2018-07-27 | PXD008448 | Pride
Decidual immune cells  infection  proteomics  tmt  toxoplasma gondii 
TranscriptomicsExpression data from CD11cHI and CD11cLO decidual macrophage populations.
Decidual macrophage populations, CD11cHI and CD11cLO cells were analyzed for expression profiles and unique characteristics. We used microarrays to detail the global program of gene expression and to determine differences between these two unique decidual macrophage populations. First trimester deci...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22342 | biostudies-arrayexpress
TranscriptomicsGene expression profile of decidual macrophages and different in vitro M1 and M2 macrophage populations
Uterine (decidual) macrophages (M) are believed to play an important role in fetal tolerance during pregnancy, but the factors that regulate them are not known. In this study we investigated the potential role of several factors (M-CSF, GM-CSF, IL-4/13, IL-10, progesterone and estradiol) to drive th...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30595 | biostudies-arrayexpress
TranscriptomicsDECIDUALIZATION INDUCES A SECRETOME SWITCH IN THE PERIVASCULAR NICHE CELLS OF THE HUMAN ENDOMETRIUM
The endometrial perivascular microenvironment is rich in mesenchymal stem-like cells that express type 1 integral membrane protein Sushi domain containing 2 (SUSD2) but the role of these cells in the decidual transformation of this tissue in pregnancy is unknown. We used an antibody directed against...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-GEOD-57182 | biostudies-arrayexpress
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
TranscriptomicsTranscription profiling of human endometrial stromal cells treated with human trophoblasts vs. control, sampled at multiple time points to investigate stromal cell response to paracrine signals from the trophoblast
During the invasive phase of implantation, trophoblasts and maternal decidual stromal cells secrete products that regulate trophoblast differentiation and migration into the maternal endometrium. Paracrine interactions between the extravillous trophoblast and the maternal decidua are important for s...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5809 | biostudies-arrayexpress
GenomicsCCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy
PRJNA1058460 | ENA
TranscriptomicsPreimplantation Factor Effect on Endometrial and Decidual Cells
Embryos secrete preimplantation factor (PIF), a peptide present in maternal circulation during viable pregnancy. We compared downstream synthetic PIF effect on gene expression in non-pregnant Human Endometrial Stromal Cell (HESC) and First Trimester Decidual cell (FTDC) culture to mimic the materna...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-46326 | biostudies-arrayexpress
GenomicsTranscriptional and Functional Programming of Decidual Innate Lymphoid Cells
Transcriptional and Functional Programming of Decidual Innate Lymphoid Cells
PRJNA531718 | ENA
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - Smartseq 2 data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. This part contains RN...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-6678 | biostudies-arrayexpress
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