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GenomicsDeep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
PRJNA1021605 | ENA
GenomicsClonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46210 | biostudies-arrayexpress
GenomicsDeep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions
Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions
PRJNA431224 | ENA
GenomicsDeep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function
Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function
PRJNA1021220 | ENA
OtherDeep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
Altered splicing is a frequent mechanism by which genetic variants cause disease. However, the regulatory architecture of human exons remains poorly understood, making the therapeutic modulation of splicing in disease challenging. Here we show that deep indel mutagenesis (DIM) provides an efficient ...
ORGANISM(S): Homo sapiens 
2025-07-08 | GSE244179 | GEO
GenomicsDeep mutagenesis reveals the distinct mutational landscape of ADan and ABri amyloid nucleation
Deep mutagenesis reveals the distinct mutational landscape of ADan and ABri amyloid nucleation
PRJNA1023889 | ENA
GenomicsDeep mutagenesis of PDGF-B reveals sequence constraints for homodimerization and high affinity receptor interactions
Deep mutagenesis of PDGF-B reveals sequence constraints for homodimerization and high affinity receptor interactions
PRJNA529784 | ENA
OtherDeep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions
The serotonin transporter, SERT, catalyzes serotonin reuptake at the synapse to terminate neurotransmission via an alternating access mechanism, and SERT inhibitors are the most widely prescribed antidepressants. Here, deep mutagenesis is used to determine the effects of nearly all amino acid substi...
ORGANISM(S): Homo sapiens 
2019-07-31 | GSE109499 | GEO
OtherDeep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function
Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels are not well understood and poorly predicted. Here we address this shortcoming by performing deep indel mutagenesis (DIM) of structurally diverse proteins...
ORGANISM(S): Saccharomyces cerevisiae 
2023-09-28 | GSE244096 | GEO
UnknownCircular permutation profiling by deep sequencing libraries created using transposon mutagenesis.
Not available
S-EPMC6061844 | biostudies-literature
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