Sort   by:  
 Page size 
TranscriptomicsDUX4 activates germline genes, retroelements and immune-mediators: Implications for facioscapulohumeral dystrophy
Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular dystrophies. The causative gene remains controversial and the mechanism of pathophysiology unknown. Here we identify genes associated with germline and early stem cell development as targets of the DUX4 transcription f...
ORGANISM(S): Homo sapiens 
2012-01-03 | E-GEOD-33799 | biostudies-arrayexpress
ProteomicsProteomic analysis of the mechanism of recombinant actifensin and defensin-d2 against multidrug-resistant Pseudomonas aeruginosa and Candida albicans
In this study, we evaluated the protein expression changes in multidrug-resistant P. aeruginosa and C. albicans treated with recombinant defensin-d2 and actifensin from spinach and Actinomyces ruminicola, respectively, for 1 h. The proteome changes in the test organisms were analyzed by LC-MS/MS ES...
ORGANISM(S): Candida albicans (Yeast) 
2022-09-17 | PXD034169 | Pride
Spinach defensin Proteomics Pseudomonas aeruginosa Actifensin Candida albicans Antimicrobial peptides Antimicrobial mechanism 
TranscriptomicsSeparated and combined effects of the over-expression of a plant defensin and of a 20 mM Zn treatment on yeast.
The expression of plant defensins in Saccharomyces cerevisiae has been shown to increase tolerance to Zn of yeast (Mirouze et al., 2006; Shahzad et al., 2013). The present transcriptomic approach has been conducted to uncover the mechanism underlying this phenotype. WT yeast was compared to yeast ex...
ORGANISM(S): Saccharomyces cerevisiae 
2015-03-31 | E-GEOD-63395 | biostudies-arrayexpress
GenomicsVigna radiata plant defensin (PDF1) gene (DNA), cultivar Dautam
Vigna radiata plant defensin (PDF1) gene (DNA), cultivar Dautam
PRJEB19663 | ENA
UnknownHuman α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet.
Not available
S-EPMC10531064 | biostudies-literature
ProteomicsImpact of an antifungal insect defensin on the proteome of the phytopathogenic fungus Botrytis cinerea
ETD151, an analogue of the antifungal insect defensin heliomicin, is an antifungal peptide active against yeasts and filamentous fungi. In order to decipher the mechanisms underlying its molecular action on the phytopathogenic fungus Botrytis cinerea, a necrotrophic pathogen responsible for gray mol...
ORGANISM(S): Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) 
2020-01-29 | PXD016740 | Pride
Insect defensin Botrytis cinerea Proteomics Heliomicin Mechanism of action Fungal infection Antifungal defensin 
TranscriptomicsDrosophila Sociality Influences Immune Peptide Load and Apoptosis-induced Tumor Suppression independently of the Antitumor Peptide Defensin
Patient’s social environment might influence cancer outcome. This potentially happens in Drosophila, as we previously reported that the social context influences the growth of intestinal tumors. To uncover the underlying social-induced physiological mechanisms, we performed RNA-seq of isogenized beh...
ORGANISM(S): Drosophila melanogaster 
2026-01-01 | E-MTAB-16147 | biostudies-arrayexpress
ProteomicsGlycoproteomic analysis of fucose-containing proteins in small intestine identified cryptdin-related sequence 1 as O-glycosylated proteins modified with α1,2-fucose
The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against infections, but the detailed molecular mechani...
ORGANISM(S): Mus Musculus (mouse) 
2020-11-05 | PXD022132 | JPOST Repository
UnknownHuman β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis.
Not available
S-EPMC7006816 | biostudies-literature
GenomicsNeutrophil-specific defensin receptors prevent skin dysbiosis and bacterial infection
Neutrophil-specific defensin receptors prevent skin dysbiosis and bacterial infection
PRJNA739453 | ENA
Sort   by:  
 Page size