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GenomicsH2A.Z (pht1) ChIP-seq data in 968, Y0036, and swc5-del strains
After finding a QTL hotspot in a fission yeast cross of strains 968xY0036 that was apparently driven by frame shift mutation in swc5 (swc5-fs), we have determined the genome-wide occupancy of the histone variant H2AZ (PhT1). Indeed swc5 has been shown to affect H2AZ occupancy. To test the impact of ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2650 | biostudies-arrayexpress
UnknownProtective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers (Meles meles) Experimentally Infected With M. bovis.
Not available
S-EPMC7011093 | biostudies-literature
TranscriptomicsA Distinct Reactive Oxygen Species Profile confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Aims: We explore the role of elevated O2-:H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers. Results: We observed that elevated O2-:H2O2 ratio conferred enhanced resistance in GPCs, and depletion of t...
ORGANISM(S): Homo sapiens 
2013-03-13 | E-GEOD-32335 | biostudies-arrayexpress
TranscriptomicsRNA coimmunoprecipitations
Nascent polypeptides emerging from the ribosome during biogenesis can interact with many chaperones and protein homeostasis factors. The high sensitivity of RNA identification can be used to identify substrates of specific cotranslationally acting chaperones. Protein A-tagged (TAP-tag) chaperones as...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45794 | biostudies-arrayexpress
GenomicsGenome-wide analysis of FNR and M-OM-^C70 in E. coli under aerobic and anaerobic growth conditions.
We found many binding sites for FNR under glucose fermentative anaerobic growth conditions. Also, many binding sites were identified for M-OM-^C70 under both aerobic and anaerobic growthin conditions. Descirbed in the manuscript "Genome-scale Analysis of E. coli FNR Reveals the Complexity of B...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41187 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles on different yeast strain mutants
Transcriptional profiles on different yeast strain mutants (DEgd2/1, DEgd2/Btt1)were identified by microarray analysis comparing total mutant RNA vs wild type RNA. Set of arrays that are part of repeated experiments
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45796 | biostudies-arrayexpress
TranscriptomicsMicroarray studies on genes stimulated by RANKL in bone marrow macrophages in a cyclooxygenase-2-dependent manner
Overall goal was to look for the differentially expressed genes between receptor activator of nuclear factor kappa-B ligand (RANKL)-stimulated wild type (WT) bone marrow macrophages (BMMs) and the BMMs in which the expression or the enzyme activity of cyclooxygenase-2 (Cox2), the major enzyme for pr...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-72047 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of developing wild type and val1 mutant Arabidopsis embryos
Developing Arabidopsis seeds accumulate oils and seed storage proteins synthesized by the pathways of primary metabolism. Seed development and metabolism are positively regulated by transcription factors belonging to the LAFL regulatory network. The VAL gene family encodes repressors of the seed m...
ORGANISM(S): Arabidopsis thaliana 
2016-02-19 | E-GEOD-74692 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of lung adenocarcinomas, induced by cRaf overexpression in lung epithelium (Agilent)
In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims ...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50752 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of lung adenocarcinomas, induced by cRaf overexpression in lung epithelium (Affymetrix)
In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims ...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50748 | biostudies-arrayexpress
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