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UnknownA Flexible Microarray Data Simulation Model.
Not available
S-EPMC5003477 | biostudies-literature
TranscriptomicsTranscriptomic analyses of duodenum from wild type and VDR-null mice
As duodenum is an important Vitamin D target organ, transcriptomic analyses were performed in this tissue. We analysed RNA extracted from duodenum of three 10 week-old wild-type and VDR-null mice using the Affymetrix Mouse Gene 2.0 ST.
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-67904 | biostudies-arrayexpress
UnknownFold change rank ordering statistics: a new method for detecting differentially expressed genes.
Not available
S-EPMC3899927 | biostudies-literature
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
TranscriptomicsMisregulation of alternative splicing of BIN1 leads to T-tubule alterations and muscle weakness in myotonic dystrophy
Myotonic dystrophes (DM), the most common adult muscular dystrophy, are the first recognized examples of RNA-mediated diseases in which expression of mutant RNAs containing expanded CUG or CCUG repeats interfere with the splicing of other mRNAs. Using whole-genome microarrays, we found that alternat...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21795 | biostudies-arrayexpress
TranscriptomicsTranscriptomic expression analysis on hippocampus samples
Hippocampus transcriptome analysis of Ms5Yah carrying a 7.7Mb deletion on chromosome 16 and wild-type littermates. We analyzed hippocampi from 8 wild-type and 9 Ms5Yah male mice using the Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool.
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-58639 | biostudies-arrayexpress
GenomicsMOF-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation [ChIP-seq]
The histone acetyltransferase (HAT) Mof is essential for mouse embryonic stem cells (mESC) pluripotency and early development. Mof is the enzymatic subunit of two different HAT complexes, MSL (Male-Specific Lethal) and NSL (Non-specific lethal). The individual contribution of MSL and NSL complexes t...
ORGANISM(S): Mus musculus 
2014-06-04 | E-GEOD-53797 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spermatogonial stem cells (SSCs) reveals PU.1 a pleiotropic regulator expressed in the first embryonic stages with a crucial function in germinal progenitors
In the adult mammalian testis, spermatogenic differentiation starts from a minute population of spermatogonial stem cells (SSCs). SSCs are generated after birth from the fetal gonocytes, themselves derived from the primordial germ cells (PGCs), which are specified during the first days after implant...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11631 | biostudies-arrayexpress
TranscriptomicsAntagonistic role of MBNL1 and LIN28 promotes specific alteration of pre-miR-1 processing and is associated with heart defects in DM
Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is caused by the expression of expanded CUG repeats, which sequester the MBNL1 RNA binding protein. Cardiac involvement, which is characterized by conduction defects and arrhythmias, is the second cause of death of DM1 pa...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-24109 | biostudies-arrayexpress
TranscriptomicsCyclin K and cyclin D1b are oncogenic in myeloma cells
To study the oncogenic potential of cyclin D1b in the context of mature B cells we generated several cell clones derived from LP-1 MM cell line expressing either cyclin D1b, Myc or cyclin K oncogenes. Transcriptomic analysis allowed us to describe several mechanisms of cyclin D1b- and K-mediated onc...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-15497 | biostudies-arrayexpress
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