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TranscriptomicsRNA-seq of human fibroblast cell cultures treated with resveratrol against DMSO treated controls, with and without siRNA treatment targeting SIRT1
Resveratrol (RSV) is a small compound with many reported beneficial effects, including increased expression of genes involved in inborn errors of metabolism. We wanted to investigate the effects of RSV on gene regulation on a global scale in order to detect new target genes for RSV mediated up-regul...
ORGANISM(S): Homo sapiens 
2018-11-12 | E-MTAB-7360 | biostudies-arrayexpress
TranscriptomicsRNA-seq of spinal cord, brain, liver, and muscle from an SMA mouse model
This study describes RNA-seq results from total spinal cord, brain, liver and muscle samples taken at PND1 and PND5 from an SMA mouse model paired with samples taken from heterozygous litter-mates. There are four mouse in each group.
ORGANISM(S): Mus musculus 
2016-08-25 | E-MTAB-3664 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human cell line HepG2 edited with CRISPR and treated with splice-switching oligo inhibiting a pseudoexon in PCCA against control SSO and control HepG2 cells
Cellular models of propionic acidemia were generated using HepG2 cells that were edited by CRISPR gene editing to introduce the pathogenic PCCA c.1285-1416A>G variant associated with propionic acidemia, and a 7 bp deletion of a predicted hnRNP A1 binding motif (c.1285-1411delTAGAACA), which causes c...
ORGANISM(S): Homo sapiens 
2023-12-10 | E-MTAB-13549 | biostudies-arrayexpress
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