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TranscriptomicsHost Factors with Reduced Expression in Two HCV Permissive Cell Lines as Compared to the Non-Permissive Parent Cell Line Huh7
Drugs directly targeting Hepatitis C (HCV) are often rendered useless by the high mutation rate of the virus. Thus, we deduce that targeting of host factor that affect HCV replication may provide enhanced therapy fort HCV infection. Hepatocyte cell line Huh7 is known to be non-permissive for Hepatit...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25156 | biostudies-arrayexpress
TranscriptomicsCREB3L1 Target Genes in Response to Hepatitis C Replicon Infection
Membrane-bound transcription factor CREB3L1 undergoes Regulated Intramembrane Proteolysis (RIP) in response to Hepatitis C infection. RIP activates CREB3L1 so that it can prevent the growth of HCV infected cells through the action of downstream genes. We over-expressed a truncated form of CREB3L1 ...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25157 | biostudies-arrayexpress
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