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TranscriptomicsSingle-cell RNA-Seq reveals dynamic, random monoallelic gene expression in mammalian cells
In the diploid genome, genes come in two copies, which can have different DNA sequence and where one is maternal and one is paternal. In a particular cell, a gene could potentially be expressed from both copies (biallelic expression) or only one (monoallelic). We performed RNA-Sequencing on individu...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-45719 | biostudies-arrayexpress
TranscriptomicsMorphological, electrophysiological and transcriptomic profiling of single neurons using Patch-seq
The mammalian neocortex is a layered sheet of neural tissue that mediates complex cognitive processes including perception and cognition. Despite its importance, we still lack detailed knowledge of the cellular components of the neocortex. Integrating morphological, electrophysiological and molecula...
ORGANISM(S): Mus musculus 
2016-01-25 | E-MTAB-4092 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of differentiating mESCs using Smart-seq3
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were adapted to 2i/LIF and female cells grown in serum/LIF conditions were differentiated using Fgf2 and Activin...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-9324 | biostudies-arrayexpress
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