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TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
GenomicsHost cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression
Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression
PRJNA168971 | ENA
TranscriptomicsHost cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression
After invading host cells, Toxoplasma gondii multiplies within a parasitophorous vacuole (PV) that is maintained by parasite proteins secreted from organelles called dense granules. Most dense granule proteins remain within the PV and few are known to access the host cell cytosol. We identify GRA16 ...
ORGANISM(S): Homo sapiens Mus musculus 
2013-02-06 | GSE38779 | GEO
UnknownDense granule biogenesis, secretion, and function in Toxoplasma gondii.
Not available
S-EPMC9482668 | biostudies-literature
TranscriptomicsExpression data from Human foreskin fibroblasts (HFFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription. HFFs were infe...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-25468 | biostudies-arrayexpress
TranscriptomicsExpression data from WT or p65-/- mouse embryonic fibroblasts (MEFs) infected with Toxoplasma gondii.
Toxoplasma strains have been shown to modulate host cell transcription. We have found a type II Toxoplasma gene, GRA15, which activates the nuclear translocation of the NF-kappaB p65 transcription factor. We used microarrays to determine how GRA15II modulates host cell transcription, and whether th...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25469 | biostudies-arrayexpress
Unknown3D ultrastructural analysis of α-granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets.
Not available
S-EPMC6971324 | biostudies-literature
UnknownSyntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.
Not available
S-EPMC4340400 | biostudies-literature
UnknownPhosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and exocytosis in Toxoplasma gondii.
Not available
S-EPMC9882004 | biostudies-literature
UnknownMechanism of platelet dense granule biogenesis: study of cargo transport and function of Rab32 and Rab38 in a model system.
Not available
S-EPMC3496959 | biostudies-literature
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