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MetabolomicsGut microbiota-derived deoxycholic acid promotes pancreatic regeneration following acute pancreatitis via Reg3a signaling pathway

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

2026-03-08 | MTBLS14000 | MetaboLights
TranscriptomicsTranscription profiling of SKGT4 and HET-1A cell lines exposed to deoxycholic acid (DCA)
This SuperSeries is composed of the following subset Series: GSE13376: Exposure of Barrett's associated adenocarcinoma cell lines SKGT4 to deoxycholic acid (DCA) GSE13378: Exposure of squamous esophageal cell line HET-1A to deoxycholic acid (DCA) Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-03-02 | E-GEOD-13400 | biostudies-arrayexpress
TranscriptomicsExposure of Barrett's associated adenocarcinoma cell lines SKGT4 to deoxycholic acid (DCA)
The involvment of bile acids such as deoxycholic acid (DCA) in gastro-esophageal reflux disease and subsequent Barrett’s metaplsia has been postulated. This study examines gene expression induced by exposure to DCA in esophageal cells and may be utilised in cross-comparisons with data derived from...
ORGANISM(S): Homo sapiens 
2010-02-28 | E-GEOD-13376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Barretts oesophagus cell line CP-A hTERT treated with deoxycholic acid and primary bile acids
The major aetiological risk factor for Barrett's oesophagus and oesophageal adenocarcinoma is gastroesophageal reflux. This study's aim was to identify genes involved in the celular response to reflux in vitro. The Barrettâ??s oesophagus cell line, CP-A hTERT, was exposed to media with acid, deoxy...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9768 | biostudies-arrayexpress
TranscriptomicsThe Microbial Metabolite Deoxycholic Acid Modulates Cholesterol Metabolism in the Germ-Free Mouse
Deoxycholic acid (DCA) is a secondary bile acid produced by a small number of commensal species of bacteria present in the mammalian gut. Elevated DCA concentration correlates with disease states including colon cancer and cholesterol gallstones, but the associated mechanisms are not fully understo...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-34730 | biostudies-arrayexpress
TranscriptomicsExposure of squamous esophageal cell line HET-1A to deoxycholic acid (DCA)
The involvment of bile acids such as deoxycholic acid (DCA) in gastro-esophageal reflux disease and subsequent Barrettâ??s metaplsia has been postulated. This study examines gene expression induced by exposure to DCA in esophageal cells and may be utilised in cross-comparisions with data derived fro...
ORGANISM(S): Homo sapiens 
2010-02-28 | E-GEOD-13378 | biostudies-arrayexpress
GenomicsEffects of deoxycholic acid on gene expression in colonic tissue of colitis mice
Effects of deoxycholic acid on gene expression in colonic tissue of colitis mice
PRJNA1037106 | ENA
TranscriptomicsEffects of deoxycholic acid on gene expression in colonic tissue of colitis mice
To investigate the roles of deoxycholic acid in the regulation of cell function and gene expression of colonic tissue, we treated colitis mice with deoxycholic acid. Then, we performed gene expression profiling analysis using data obtained from RNA-seq of colonic tissue of colitis mice treated with ...
ORGANISM(S): Mus musculus 
2023-11-13 | GSE247321 | GEO
MetabolomicsEffects of Guanxinning tablet on the gut microbiota and bile acid metabolism in mice with hyperlipidemia

Introduction: Guanxinning tablet (GXNT), a traditional Chinese medicine preparation, has been found to improve lipid metabolism in patients with cardiovascular disease. However, the underlying mechanisms are still poorly understood. This study aims to determine whether the gut micr...

2026-03-20 | MTBLS14095 | MetaboLights
MetabolomicsGut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

The co-occurrence of gut microbiota dysbiosis and bile acids (BAs) metabolism alteration has been reported in several human liver diseases. However, the gut microbiota dysbiosis in infantile cholestatic jaundice (CJ), and the linkage between gut bacterial changes and alterations of BAs metabolism...

2019-11-30 | MTBLS1295 | MetaboLights
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