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MetabolomicsMulti-omics Elucidates Gut Microbiota-Driven Mechanisms of Lipid Deposition in Pigs Fed a DDGS Diet

Abstract:

Background: Corn dried distillers’ grains with solubles (DDGS) is a cost-effective alternative feed ingredient in swine diets. However, its negative impact on carcass fat quality, characterized by increased polyunsaturated fatty acids (PUFAs) and reduced fat firmness, fundamentall...

2026-03-16 | MTBLS14058 | MetaboLights
MetabolomicsFat Deposition in the Muscle of Female and Male Yak and the Correlation of Yak Meat Quality with Fat

Background:

The study of fat deposition in yaks of different gender plays a positive role in improving the meat quality and breeding of yaks. In this work, the characteristic of fat deposition in male and female yaks, and the regulations of gender difference to fat deposition in yaks were ...
2021-08-04 | MTBLS2737 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
MetabolomicsLipidomics study of different fat deposition sites in wuzhishan pigs with double knockout of APOE/LDLR
Apolipoprotein E (APOE) and the low-density lipoprotein receptor (LDLR) play a key role in regulating lipoprotein transport and cholesterol homeostasis. However, their roles in porcine fat deposition and adipose tissue remodelling are not well understood. This study utilised wild-type (WT) and APOE/...
2026-09-09 | MTBLS15330 | MetaboLights
MetabolomicsRumen unprotected glucose tends to promote intramuscular fat deposition via microbial volatile fatty acid-mediated metabolic reprogramming in cattle: A multi-omics perspective through the rumen-jejunum axis

Background: The regulatory effects of glucose absorption at different sites (rumen vs. small intestine) on lipid metabolism exhibit significant variation in beef nutrition. This study aimed to investigate the regulatory pathways of rumen-protected or unprotected glucose on lipid metabolism throug...

2026-03-25 | MTBLS14139 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
MetabolomicsThe effects of birth weight and breeding value for protein deposition on the urine metabolome in growing pigs (part-III)
Not available
ORGANISM(S): Sus scrofa 
ST001724 | MetabolomicsWorkbench
MetabolomicsThe effects of birth weight and breeding value for protein deposition on the plasma metabolome in growing pigs (part-II)
Not available
ORGANISM(S): Sus scrofa 
ST001723 | MetabolomicsWorkbench
MetabolomicsThe effects of birth weight and breeding value for protein deposition on the plasma metabolome in growing pigs (part-I)
Not available
ORGANISM(S): Sus scrofa 
ST001722 | MetabolomicsWorkbench
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