Sort   by:  
 Page size 
TranscriptomicsChromatin immunoprecipitation of human HEK cells immunoprecipitated by Staufen1
In human cells, Staufen1 is double-stranded RNA-binding protein involved in several cellular functions including mRNA localization, translation and decay. We used a genome wide approach to identify and compare the mRNA targets of mammalian Staufen1. The mRNA content of Staufen1 mRNPs was identified ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8438 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human HEK293 cells transiantly transfected with plasmids coding for Staufen2-HA isoforms
In human cells, Staufen2 is a double-stranded RNA-binding protein involved in several cellular functions. Although 51% identical to Staufen1, these proteins are nevertheless found in different RNA particles. In addition, differential splicing events generate Staufen2 isoforms that only differ at the...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8437 | biostudies-arrayexpress
ProteomicsA degradation motif in STAU1 defines a novel family of proteins involved in inflammation
Cancer development is regulated by inflammation. Staufen 1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 expression levels are downregulated during mitosis due to its degradation by the E3 ubiquitin li...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036675 | Pride
Staufen 1  human  inflammation  protein degradation  e3-ubiquitin ligase  degron  trim25 
TranscriptomicssiRNA of human HeLa cells reveals Staufen1 regulates a variety of mammalian transcripts
It is currently unknown how extensively the double-stranded RNA binding protein Staufen (Stau)1 is utilized by mammalian cells to regulate gene expression. To date, Stau1 binding to the 3’ untranslated region (3’UTR) of ARF1 mRNA has been shown to target ARF1 mRNA for Stau1-mediated mRNA decay ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6679 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mRNAs expression in prometaphase
The goal of this experiment was to compare the transcriptome of cells that overexpressed the RNA-binding protein Staufen1 to that of cells that expressed the empty vector as control. Stau1 abundance fluctuates through the cell cycle: it is high in the G2 phase of the cell cycle and rapidly decreases...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-51182 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Staufen1-bound mRNAs in prometaphase
The goal of this experiment was to identify Staufen1-bound mRNAs in prometaphase cells. Stau1 abundance fluctuates through the cell cycle: it is high in the G2 phase of the cell cycle and rapidly decreases as cells transit through mitosis. The importance of controlling Stau1 levels was underscored b...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-51183 | biostudies-arrayexpress
ProteomicsA degradation motif in STAU1 defines a novel family of proteins involved in inflammation
Cancer development is regulated by inflammation. Staufen 1 (STAU1) is an RNA-binding protein whose expression level is critical in cancer cells as it is related to cell proliferation or cell death. STAU1 expression levels are downregulated during mitosis due to its degradation by the E3 ubiquitin li...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD037703 | Pride
Staufen 1  human  inflammation  protein degradation  e3-ubiquitin ligase  degron  trim25 
Sort   by:  
 Page size