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TranscriptomicsTranscription profiling of mouse liver and kidney from PAR bZip triple knockout mice to wild-type or heterozygous mutant mice to identify genes contributing to the morbidity of PAR bZIP triple KO mice and circadian liver detoxification
The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF accumulate in a highly circadian manner in several peripheral tissues, including liver and kidney. Mice devoid of all three of these proteins are born at expected Mendelian ratios, but are epilepsy-prone, age at a...
ORGANISM(S): Mus musculus 
2006-12-20 | E-MEXP-565 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse motorneurons during progression of the disease in transgenic SOD1(G93A) mice that develop motorneuron loss
To identify candidate genes that may be involved in motoneuron degeneration, we combined laser capture microdissection with microarray technology. Gene expression in motoneurons was analyzed during the progression of the disease in transgenic SOD1(G93A) mice that develop motoneuron loss. Three major...
ORGANISM(S): Mus musculus 
2005-10-30 | E-MEXP-453 | biostudies-arrayexpress
TranscriptomicsMaize primary roots: inbred lines vs. hybrids
The phenomenon of heterosis describes the increased agronomic performance of heterozygous F1-plants compared to their homozygous parental inbred plants. Heterosis is already manifested during the early stages of root development in maize. The goal of this study was to identify non-additive gene expr...
ORGANISM(S): Zea mays 
2008-02-16 | E-GEOD-10539 | biostudies-arrayexpress
TranscriptomicsComparison of age-related changes in gene expression of 2 rat skeletal muscles
In this study we compared Gastrocnemius and Triceps gene expression with age. Our results show that gene expression is massively modulated with age in Gastroc but on the contrary very stable in Triceps, suggesting that Triceps is resistant to age-related defects. 3 groups of age (8 months, 18 months...
ORGANISM(S): Rattus norvegicus 
2016-05-12 | E-GEOD-78702 | biostudies-arrayexpress
TranscriptomicsCircadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver [RNASeq]
Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living organisms. Such oscillations are controlled by the interplay between the circadian clock and feeding rhythms. While rhythmic mRNA accumulation has been extensively studied, comparatively less is known ab...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-73552 | biostudies-arrayexpress
TranscriptomicsComparative analysis of genomic features of human HIV-1 infection and primate models of SIV infection
High levels of HIV-1 replication during the chronic phase of infection are usually associated with rapid disease progression (RP). However, a minority of HIV-infected individuals remain asymptomatic and show persistently high CD4+ T cell counts despite high viremia for many years (viremic non progre...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-28128 | biostudies-arrayexpress
TranscriptomicsNef Gene expression during sex determination
Expression profiles of XX and XY somatic gonadal compartment during sex determination. This experiment was updated in March 2011 to correct the incorrect age value for sample Female E10.5_6 (was 11 days should be 10.5).
ORGANISM(S): Mus musculus 
2006-01-01 | E-MEXP-454 | biostudies-arrayexpress
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