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TranscriptomicsIdentification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming
Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly impro...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-70921 | biostudies-arrayexpress
UnknownTargeting SUMO2 Reverses Aberrant Epigenetic Rewiring Driven by SS18::SSX Fusion Oncoproteins and Impairs Sarcomagenesis
Not available
S-SCDT-10_1038-S44318-025-00526-W | biostudies-other
ProteomicsLoss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis
Here we utilized a mouse model of PDAC and human pancreatic cancer cell lines to investigate the role of HIF1alpha in pancreatic cancer. Contrary to the conventional notion that HIF1alpha plays a tumor promoting role in several cancers, our findings indicate a tumor suppressive role of HIF1alpha in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-21 | MSV000084223 | MassIVE
TranscriptomicsIdentification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming
Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly impro...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-60790 | biostudies-arrayexpress
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