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GenomicsProteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)
Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
GenomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Designed, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
PRJNA1268535 | ENA
GenomicsTargeted resequencing of ribosomal proteins in multiple myeloma patient samples.
We studied 38 multiple myeloma samples to discover mutations in ribosomal proteins. To this end, we ran a specifically designed targeted resequencing study to resequence the coding regions of all ribosomal proteins.
EGAS00001002405 | EGA
UnknownAssessing and enhancing foldability in designed proteins.
Not available
S-EPMC9375437 | biostudies-literature
UnknownAmino-acid site variability among natural and designed proteins.
Not available
S-EPMC3828621 | biostudies-literature
UnknownThe stability and dynamics of computationally designed proteins.
Not available
S-EPMC9214642 | biostudies-literature
OtherComputationally designed, high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
In the related work, proteins were computationally designed and experimentally optimized to bind with high affinity and specificity to each human pro-survival BCL2 homolog. Site-directed saturation mutagenesis libraries were generated based on partially-specific computational designs 2CDP06 (for Bcl...
ORGANISM(S): Saccharomyces cerevisiae 
2016-05-09 | GSE80194 | GEO
ProteomicsDe novo designed protein guiding targeted protein degradation
Targeted protein degradation is a powerful tool for biological research, cell therapy, and synthetic biology. However, conventional methods often depend on pre-fused degrons or chemical degraders, limiting their wider applications. In this study, a guided protein labeling and degradation system (GPl...
ORGANISM(S): Escherichia coli 
2025-07-05 | PXD063956 | Pride
Protein degradation  protein design 
UnknownStructure-based optimization of designed Armadillo-repeat proteins.
Not available
S-EPMC3403439 | biostudies-literature
UnknownAutomated selection of stabilizing mutations in designed and natural proteins.
Not available
S-EPMC3277135 | biostudies-literature
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