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TranscriptomicsmRNA profiling reveals divergent roles of PPARa and PPARÃ?/d in regulating mouse liver gene expression (PPARa samples)
Little is known about the role of the transcription factor PPARÃ?/d in liver. Here we set out to better elucidate the function of PPARÃ?/d in liver by comparing the effect of PPARa and PPARÃ?/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed...
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-17863 | biostudies-arrayexpress
UnknownIntegrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.
Not available
S-EPMC4419664 | biostudies-literature
GenomicsGenome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle
To understand the transcriptional basis of circadian rhythms in mouse liver, we generated genome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle. We found that Pol 2 occupancy at promoters and in gene bodies cycle...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35788 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver cells during the circadian cycle at 4 hour time resolution
Cyclic regulatory systems are ubiquitous in cells and tissues. In the liver rhythms in mRNA expression are determined by the homeostatic regulation that operates on daily circumstances. In particular the specific response to nutrients, as well as systemic and peripheral circadian oscillators, contri...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35789 | biostudies-arrayexpress
GenomicsKinetic RNA polymerase II occupancy, associated histone marks, and mRNA accumulation reveal transcriptional and post-transcriptional mechanisms underlying circadian gene expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35790 | biostudies-arrayexpress
UnknownPeroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.
Not available
S-EPMC2786701 | biostudies-literature
TranscriptomicsTranscription profiling of mouse white adipose tissue from PPARb/d knockout
Analysis of white adipose tissue of PPARb/d knockout mice. Data may point towards putative target genes of PPARb/d and thus the function of PPARb/d in white adipose tissue. Datasets were used to identify glycogen synthase 2 as novel PPAR target. Experiment Overall Design: Three month old male PPARb/...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8344 | biostudies-arrayexpress
UnknownCritical roles of PPAR beta/delta in keratinocyte response to inflammation.
Not available
S-EPMC312855 | biostudies-literature
UnknownSystem analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.
Not available
S-EPMC6705839 | biostudies-literature
UnknownMay direct-to-consumer genetic testing have an impact on general practitioners' daily practice? a cross-sectional study of patients' intentions towards this approach.
Not available
S-EPMC8077756 | biostudies-literature
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