Deubiquitinating enzyme

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MRC Protein Phosphorylation & Ubiquitylation Unit School of Life Sciences Sir James Black Centre University of Dundee Dundee DD1 5EH, UK. (1)
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Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (1)
TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK (1)
Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute (1)

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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...

ORGANISM(S): Homo Sapiens Mus Musculus

PXD053163 |

The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival

PRJNA1207084 | ENA

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response [CRISPR]

PRJNA1061568 | ENA

Transcriptional studies on the deubiquitinating enzyme Ubp10

Transcriptional analises of ubp10 null mutant, wild type and related null mutants. Keywords = deubiquitinating enzymes Keywords = yeast Keywords: repeat sample

ORGANISM(S): Saccharomyces cerevisiae

2004-02-01 | GSE804 | GEO

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response [RNA-seq]

PRJNA1061575 | ENA

Deubiquitinating enzyme VCPIP1 in DOX-induced cardiotoxicity

PRJNA1397152 | ENA

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response

PRJNA1061572 | ENA

Saccharomyces cerevisiae

Transcriptional studies on the deubiquitinating enzyme Ubp10

PRJNA87781 | ENA

FIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.

The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-03-28 | MSV000080695 | MassIVE

Hewings et al. 2018

raw data files associated with manuscript titled "Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes". Result file includes all PSMs identified in the experiment after performing necessary quality filter.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2018-01-25 | MSV000081972 | MassIVE

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