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GenomicsGenome wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
We have identfied antibodies that support chromatin immunoprecipitation (ChIP) of 11 components of Polycomb repressive complex 1 (PRC1) and shown that multiple variants of PRC1 associate with the same DNA. By performing ChIP-seq with antibodies against CBX6, CBX7, CBX8, RING1 and RING2, in two stra...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-40740 | biostudies-arrayexpress
TranscriptomicsGerminal Center B-Cell gene expression comparison between Wiskott-Aldrich syndrome protein KO mice and WT mice
This experiment intended to define differential gene expression between germinal center B cells expressing or not the Wiskott-Aldrich syndrome protein in mice. Sequencing was obtained on an Illumina HiSeq2500 system from Dark Zone GCB (DAPI-CD19+ GL7+IgD-CXCR4highCD86low) purified from CTL and GCBc...
ORGANISM(S): Mus musculus 
2021-06-01 | E-MTAB-10056 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
UnknownDiscovery and validation of cell cycle arrest biomarkers in human acute kidney injury.
Not available
S-EPMC4057242 | biostudies-literature
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