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TranscriptomicsA small molecule approach to engineering vascularized tissue
The repertoire of growth factors determines the biological engagement of human mesenchymal stromal cells (hMSCs) in processes such as immunomodulation and tissue repair. Hypoxia is a strong modulator of the secretome and well known stimuli to increase the secretion of pro-angiogenic molecules. In th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7209 | biostudies-arrayexpress
TranscriptomicsIrp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading
Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic associa...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-57073 | biostudies-arrayexpress
ProteomicsUnravelling the Mechanism of DFO/DpT44mt-Induced Cell Death in breast cancer cells
Iron is required as a cofactor for many critical cellular enzymes involved in energy metabolism and cell proliferation and is thus essential for all living cells. To facilitate the rapid replication, the neoplastic cells have significantly higher levels of ribonucleotide reductase and the transferri...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007595 | Pride
Di-2-pyridylketone 4 Lc/ms-ms analyses. Iron chelator 4-dimethyl-3-thiosemicarbazone Flow cytometry Di-2-pyridylketone thiosemicarbazone scaffold Iron Deferoxamine 
GenomicsMicroarray gene expression profiling of mouse HSC treated with iron chelator deferoxamine (DFO)
Microarray gene expression profiling of mouse HSC treated with iron chelator deferoxamine (DFO)
PRJNA662912 | ENA
UnknownDirect comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET.
Not available
S-EPMC6647232 | biostudies-literature
GenomicsDFO - beads in situ microcosms
DFO - beads in situ microcosms Raw sequence reads
PRJNA629517 | ENA
UnknownComparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET.
Not available
S-EPMC5215071 | biostudies-literature
UnknownEvaluation of DFO-HOPO as an octadentate chelator for zirconium-89.
Not available
S-EPMC6055981 | biostudies-literature
TranscriptomicsMicroarray gene expression profiling of mouse HSC treated with iron chelator deferoxamine (DFO)
We delineted the role for the intracellular labile iron pool in coordinating a cascade of molecular events which reinforce hematopoietic stem cell (HSC) identity by charaterizing and comparing the transciptome of HSC treated for 16hrs with an iron chlator (DFO, 10uM) vs. mock controls.
ORGANISM(S): Mus musculus 
2024-12-25 | GSE157817 | GEO
TranscriptomicsTranscription profiling of human U251 cells treated with hypoxia inducible factor HIF-1I siRNA or a polyamide targeted against the hypoxia response element (HRE) after induction of hypoxia
Transcription mediated by hypoxia inducible factor (HIF-1) contributes to tumor angiogenesis and metastasis but is also involved in the activation of cell-death pathways and normal physiological processes. Given the complexity of HIF-1 signaling it could be advantageous to target a subset of HIF-1 ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7835 | biostudies-arrayexpress
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