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MetabolomicsEvidence of a DHA signature in the lipidome and metabolome of human hepatocytes
Cell supplementation with bioactive molecules often causes a perturbation in the whole intracellular environment. Omics techniques can be applied for the assessment of this perturbation. In this study, the overall effect of docosahexaenoic acid (DHA) supplementation on cultured human hepatocyte lipi...
2017-03-02 | MTBLS419 | MetaboLights
TranscriptomicsTranscription profiling of blood cells from hypertriglyceridemic men treated with docosahexaenoic acid shows suppression of LDLR and OLR1 gene expression.
Previously published results from our double-blind, placebo-controlled parallel study with docosahexaenoic acid (DHA) supplementation (3 g/d, 90 d) to hypertriglyceridemic men (39-66yr) showed that DHA reduced several risk factors for cardiovascular disease (CVD), including the plasma concentration ...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20114 | biostudies-arrayexpress
MetabolomicsDifferential interactions of dietary EPA and DHA with the gut microbiota dictate distinct metabolic outcomes in the host

Background: Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to modulate host physiology, but their differential interactions with the gut microbiota and consequent host metabolic effects remain poorly understood.

Methods: We employed shotgun metagenomics, untargeted met...

2026-01-31 | MTBLS13495 | MetaboLights
MetabolomicsDifferential interactions of dietary EPA and DHA with the gut microbiota dictate distinct metabolic outcomes in the host

Background: Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to modulate host physiology, but their differential interactions with the gut microbiota and consequent host metabolic effects remain poorly understood.

Methods: We employed shotgun metagenomics, untargeted met...

2026-01-31 | MTBLS13497 | MetaboLights
TranscriptomicsTranscriptional pattern of E. coli BW25113 and its ptsA, glpK and dhaKLM isogenic mutants growing on DHA (dihydroxyacetone).
Dihydroxyacetone (DHA) is an attractive molecule produced in a wide range of industries . DHA is found among all the kingdoms as an intermediate of various metabolic pathways and can be used as a carbon source by many organisms. The bacterium Escherichia coli is able to grow on DHA as the sole carbo...
ORGANISM(S): Escherichia coli K-12 
2019-06-03 | E-MTAB-7666 | biostudies-arrayexpress
TranscriptomicsEffect of treatment OPM2 multiple myeloma cells with EPA, DHA or bortezomib
OPM2 cells were seeded in a 12-well plate at density of 10 × 103 cells/well and incubated with the indicated concentrations of compounds. OPM2 cells were treated with 50 µM of DHA/EPA (6 h) or 10 nM of bortezomib (4 h). Total RNA was extracted from cells using RNeasy Mini Kit (74104, Qiagen, Hilden,...
ORGANISM(S): Homo sapiens 
2022-06-26 | E-MTAB-11907 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Several studies indicate that omega (n)-3 fatty acids may have a potential in the prevention and treatment of cancer. In this study the colon cancer cell lines SW480 and SW620 were treated with the n-3 PUFA DHA (Docosahexaenoic acid) for 3 different time points (12, 24 and 48h). The experiments were...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer cell line SW620 treated with docosahexaenoic acid
The human colon cancer cell line SW620 was supplemented with DHA (70 µM) or an equal volume of ethanol (control). Total RNA was isolated after 6 h and used for Affymetrix gene expression profiling.
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-2010 | biostudies-arrayexpress
TranscriptomicsEffects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
The hypothesis was that 6 months of dietary n-3 FA supplementation to humans affected expression of genes that might be of significance for inflammatory processes and for Alzheimer´s disease. Effects on global gene expression profiles (Affymetrix Human Focus array) in human blood mononuclear leukocy...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-29680 | biostudies-arrayexpress
TranscriptomicsDHA effect on endothelial cells (HUVEC) under proinflammatory condition
Transcriptional profiling of Human Umbilical Vein Endothelial Cells (HUVEC) comparing untreated control cells with IL-1-treated cells with or without pre-treatment with DHA. Three condition experiment: DHA treated HUVEC cells (25 µmol/L DHA for 48 hours) vs control; IL-1 treated HUVEC cells (5ng/m...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-57825 | biostudies-arrayexpress
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