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YTHDF1 CLIP-seq in WT and DHX36-KO HEK293T cells
Adult muscle stem cells, also known as satellite cells (SCs) play pivotal roles in injury induced muscle regeneration and our knowledge of long non-coding RNA (lncRNA) functions in SCs remains limited. Here we identify a lncRNA, Lockd which is induced in activated SCs upon acute muscle injury. We de...
ORGANISM(S): Mus Musculus 
2022-05-24 | PXD033658 |
DNA/RNA helicase DHX36 is required for late stages of spermatogenesis
Transcriptomic RNA structure mapping unveils the structure dynamic induced by DHX36 binding (RBNS)
This experiment aimed to investigate the transcriptional role of G4 resolvase Dhx36 in the adult mouse heart. We compared three pools of wild-type (WT) mouse hearts with three pools of Dhx36 conditional knockout (cKO) hearts. In the mutant mice, Dhx36 was conditionally deleted in cardiomyocytes usin...
ORGANISM(S): Mus musculus 
RNA-seq comparing the WT mouse hearts versus Dhx36 cKO hearts
Rapid degradation of DHX36 revealing its transcriptional role by interacting with G-quadruplex
Transcriptomic RNA structure mapping unveils the structure dynamic induced by DHX36 binding (Structure-seq)
DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A/YTHDF1
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