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TranscriptomicsProfiling of Mili and Miwi2 associated piRNAs in WT, MiliDAH, Miwi2DAH and Miwi2KO from E16.5 gonadocytes.
Piwi proteins and piRNAs have conserved functions in transposonM- silencing. The murine Piwi proteins Mili and Miwi2 direct epigeneticM- LINE1 (L1) and intracisternal A particle (IAP) transposon silencingM- during genome reprogramming in the embryonic male germline. PiwiM- proteins are proposed to b...
ORGANISM(S): Mus musculus 
2011-10-28 | E-MTAB-730 | biostudies-arrayexpress
TranscriptomicsMultiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis
The Piwi protein Mili and the Piwi-interacting RNA (piRNA) pathway are required to establish L1 DNA methylation during epigenetic reprogramming that accompanies male germ cell development. Although Mili is expressed throughout most of adult spermatogenesis, its function therein remains unknown. We f...
ORGANISM(S): Mus musculus 
2013-07-03 | E-MTAB-1557 | biostudies-arrayexpress
MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
UnknownThe role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.
Not available
S-EPMC10513414 | biostudies-literature
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