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TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38613 | biostudies-arrayexpress
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38611 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of enzastaurin-treated B cell lymphoma RL cells
Follicular lymphoma (FL) is an indolent lymphoma associated with follicular center B cells, and typically contains the Bcl-2 chromosomal translocation t(14;18), which leads to overexpression of the anti-apoptotic intracellular protein Bcl-2. FLs are sensitive to chemotherapy; however, patient relaps...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-24183 | biostudies-arrayexpress
UnknownCardiac surgery practice during the COVID-19 outbreak: a multicentre national survey.

Objectives

Healthcare systems worldwide have been overburdened by the coronavirus disease 2019 (COVID-19) outbreak. Accordingly, hospitals had to implement strategies to profoundly reshape both non-COVID-19 medical care and surgical activities. Knowledge about the impact of the COVID-19 pand...
S-EPMC7989504 | biostudies-literature
TranscriptomicsGenomic approach in B-cell Chronic Lymphocytic Leukemia: molecularly distinct subgroups of patients with 13q14 deletion
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by a highly variable clinical course that reflects its heterogeneous genomic pattern. To better define molecular subtypes of the disease, we performed SNP and gene expression profiling microarray analyses in a panel of early stage (Binet A...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-16746 | biostudies-arrayexpress
UnknownKDM6A Loss Enhances Oxidative Phosphorylation Uncovering Tissue-Level Convergent Evolution
The tumor suppressor KDM6A/UTX, a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic environment, opposite from the pse...
S-SCDT-10_1038-S44318-026-00891-0 | biostudies-other
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