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MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we analyze MRSA/CRE b...

2026-01-06 | MTBLS13611 | MetaboLights
TranscriptomicsComparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin [nanoString nCounter miR expression assay]
Diabetes Mellitus (DM) is a chronic, severe disease rapidly increasing in incidence and prevalence and is associated with numerous complications. Patients with DM are at high risk of developing diabetic foot ulcers (DFU) that often lead to lower limb amputations, long term disability, and a shortene...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-68185 | biostudies-arrayexpress
GenomicsCharacterization of Diabetic and Non-Diabetic Foot Ulcers Using Single-Cell RNA-Sequencing
Characterization of Diabetic and Non-Diabetic Foot Ulcers Using Single-Cell RNA-Sequencing
PRJNA1043098 | ENA
GenomicsGene expression profile as single cell level of chronic diabetic foot ulcers and chronic non-diabetic foot ulcer
Gene expression profile as single cell level of chronic diabetic foot ulcers and chronic non-diabetic foot ulcer
PRJNA929216 | ENA
TranscriptomicsSingle Cell Transcriptomic Landscape of Diabetic Foot Ulcers
Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. In order to identify systemic and local factors associated with DFU healing, we examined the cellular landscape of DFUs by single-cell RNA-seq analysis of foot and forearm skin specimens, as well as PBMC samples, from 10 non-dia...
ORGANISM(S): Homo sapiens 
2021-11-01 | GSE165816 | GEO
GenomicsCircular RNA expression profiling in diabetic foot ulcers and human normal acute wounds
Circular RNA expression profiling in diabetic foot ulcers and human normal acute wounds
PRJNA470663 | ENA
UnknownBurden of Infected Diabetic Foot Ulcers on Hospital Admissions and Costs.
Not available
S-EPMC6048950 | biostudies-literature
UnknownThe Influence of Multidrug-Resistant Bacteria on Clinical Outcomes of Diabetic Foot Ulcers: A Systematic Review.
Not available
S-EPMC8124692 | biostudies-literature
TranscriptomicsCircular RNA expression profiling in diabetic foot ulcers and human normal acute wounds
Circular RNA (circRNA) microarray analysis was performed to examine the expression profiles of circRNAs in diabetic foot ulcers (DFU) and in human excisional skin wounds 7 days after injury.
ORGANISM(S): Homo sapiens 
2019-10-01 | GSE114248 | GEO
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