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MetabolomicsGut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy

Diabetic mellitus nephropathy (DMN) is a serious complication of diabetes and a major health concern. Although the pathophysiology of diabetes mellitus (DM) leading to DMN is uncertain, recent evidence suggests the involvement of the gut microbiome. This study aimed to determine the relationships...

2023-03-01 | MTBLS6331 | MetaboLights
MetabolomicsMetabolomics of diabetic nephropathy
Not available
ORGANISM(S): Homo sapiens 
ST000691 | MetabolomicsWorkbench
TranscriptomicsGene expression profiling in glomeruli from human kidneys with diabetic nephropathy
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2004-04-01 | E-GEOD-1009 | biostudies-arrayexpress
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
ProteomicsProteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients
In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.
ORGANISM(S): Homo Sapiens 
2021-12-29 | PXD030660 |
TranscriptomicsRNA-Seq of Kidney Glomeruli from Type 2 diabetic (db/db) and non-diabetic mice
We investigated the gene expression profiles of RNA isolated from kidney glomeruli from aged, 25 week old type-2 diabetic (db/db) and non-diabetic mice. In order to investigate the consequences of hyperglycemia on the pathogenesis and progression of diabetic nephropathy Kidney glomeruli from 3 diabe...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-77717 | biostudies-arrayexpress
TranscriptomicsSystematic analysis of a human renal transcript dataset
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal glomerulus. To identify additional candidate genes ...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21785 | biostudies-arrayexpress
TranscriptomicsInteraction between diabetes and hypertension in a rat model of diabetic nephropathy
Fisher male Cyp1a1mRen2 rats were allocated into four groups of four biological replicates each: control; streptozotocin-induced diabetes alone; indole-3-carbinol induced hypertension alone; combined induced diabetes and hypertension.
Kidneys were harvested for microarray analysis.analysis.
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-MEXP-3165 | biostudies-arrayexpress
MetabolomicsPlasma metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model
Not available
ORGANISM(S): Mus musculus 
ST000558 | MetabolomicsWorkbench
MetabolomicsKidney tissue metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model.
Not available
ORGANISM(S): Mus musculus 
ST000540 | MetabolomicsWorkbench
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