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GenomicsThe diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
The diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
PRJNA1076844 | ENA
ProteomicsDiadenosine tetraphosphate as a cosubstrate for AMPylation mediated by FICD
Diadenosine polyphosphates (ApnAs) are noncanonical nucleotides that are ubiquitous across all forms of life. Due to their strong accumulation upon cellular stress, they are considered alarmones to signal homeostatic imbalance. Nonetheless, their cellular role is poorly understood. In this work, we ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-27 | PXD036450 | Pride
Diadenosine tetraphosphate Ampylation Ficd Post-translational modification Proteomics 
TranscriptomicsThe diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
The role of the intracellular signaling molecule diadenosine tetraphosphate (Ap4A) has not so far been investigated in Pseudomonas aeruginosa. To fill this gap, we performed RNA sequencing (RNA-seq) analysis to compare the transcriptome of the reference strain P. aeruginosa PAO1 and an isogenic dele...
ORGANISM(S): Pseudomonas aeruginosa 
2024-08-07 | GSE255863 | GEO
ProteomicsChemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However, their cellu...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-15 | PXD020740 | Pride
Photo-affinity labeling Proteomics Apna 
UnknownThe mysterious diadenosine tetraphosphate (AP4A).
Not available
S-EPMC10148737 | biostudies-literature
UnknownDiadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis.
Not available
S-EPMC10439310 | biostudies-literature
UnknownChemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate.
Not available
S-EPMC8490401 | biostudies-literature
UnknownStructural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase.
Not available
S-EPMC4734340 | biostudies-literature
UnknownDiadenosine tetraphosphate modulated quorum sensing in bacteria treated with kanamycin.
Not available
S-EPMC10657157 | biostudies-literature
UnknownLysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Not available
S-EPMC7244319 | biostudies-literature
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