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MetabolomicsNon-invasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer
Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1500 Da) were measured in urine collected from 469 lung cancer patients and 536 population controls using u...
2014-05-06 | MTBLS28 | MetaboLights
MetabolomicsMicrobiome and Metabolome Integrated Analysis: Exploring Potential Diagnostic Approaches for Parkinson’s Disease Using Tongue Coating Samples

Parkinson's disease (PD) is a prevalent neurodegenerative disorder with complex pathogenesis and limited treatment options. The current reliance on clinical evaluation for diagnosis, due to the absence of reliable non-invasive methods, presents significant challenges. Traditional diagnostic appro...

2025-07-05 | MTBLS12679 | MetaboLights
MetabolomicsDistinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma

Germline or somatic loss-of-function of fumarate hydratase (FH) predisposes patients to an aggressive form of renal cell carcinoma (RCC). Since other than tumor resection, there is no effective therapy for FH-deficient RCC, a competent method for early diagnosis and for early detection of recurre...

2022-08-12 | MTBLS3628 | MetaboLights
MetabolomicsMaHPIC Experiment HuB - Metabolomics analysis of human plasma from patients infected with Plasmodium falciparum and P.vivax for discovery of diagnostic markers of malaria
MaHPIC Experimental Description:
This study is based on archived plasma from samples collected between 2011 and 2014. Patients in Thailand who were infected with Plasmodium falciparum (30 subjects), P. vivax (30 subjects), co-infected with P. falciparum and P. viv...
2018-09-05 | MTBLS664 | MetaboLights
ProteomicsSystematic Evaluation and Optimization of Protein Extraction Parameters in Diagnostic FFPE Specimens
Objectives: Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for di-agnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While numerous extraction pro-tocols and chemicals have been described, systematic c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029133 | Pride
Protein extraction  formalin-fixed paraffin-embedded tissue  clinical prote-omics  antigen retrieval  crosslinking reversal  protein analysis  biomarker 
TranscriptomicsSBV - Gene Expression Profiles of Lung Cancer Tumors - Adenocarcinomas and Squamous Cell Carcinomas
This dataset encompassing the profiles of 150 lung cancer tumors was developed to serve as test dataset in the SBV IMPROVER Diagnostic Signature Challenge (sbvimprover.com). The aim of this subchallenge was to verify that it is possible to extract a robust diagnostic signature from gene expression d...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-43580 | biostudies-arrayexpress
TranscriptomicsEffects of moderate ethanol consumption during pregnancy on placental gene expression
We conducted a preliminary investigation to determine whether ethanol-induced alterations in placental gene expression may have some utility as a diagnostic indicator of maternal drinking during pregnancy as well as a prognostic indicator of risk for adverse neurobehavioral outcomes in affected offs...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-18162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblast-TBX2 cells treated with LPA or EGF and their inhibitors
EXPERIMENT 4: Effect of inhibitors on 4 hrs LPA response Concentration LPA 5 uM Concentration AG1478/PD168393 250 nM Concentration PTX 200 ng/ml
ORGANISM(S): Mus musculus 
2009-02-14 | E-NCMF-19 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of time series of mouse embryonic fibroblast-TBX2 cells treated with LPA at different concentrations
EXPERIMENT 2: LPA concentration and time series LPA concentration 0.3, 1.0 and 5.0 uM Time series 0.5, 1, 2 and 4 hrs
ORGANISM(S): Mus musculus 
2009-02-14 | E-NCMF-17 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblast-TBX2 cells treated with LPA or EGF
EXPERIMENT 3: LPA compared to EGF response; LPA concentration 5uM; EGF concentration 50ng/ml
ORGANISM(S): Mus musculus 
2009-02-14 | E-NCMF-18 | biostudies-arrayexpress
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