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ProteomicsCharacterization of the human urinary proteome and peptidome
Urine represents an ideal source of clinically relevant biomarkers since it contains a large number of proteins and low molecular weight peptides. Characterization of the normal urinary proteome and peptidome can serve as a reference for disease and can aid in biomarker discovery. Proteomic and pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080263 | MassIVE
ProteomicsProteomic Profiling of the Human Tissue and Biological Fluid Proteome
Here, we performed label-free liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) to profile the normal human proteome. In total, we analyzed 117 samples from 46 histologically normal tissues and organs at autopsy. Our high-resolution MS approach allowed for the quantification of 10...
ORGANISM(S): Homo sapiens (Human) 
2020-10-29 | PXD020192 | Pride
Biological fluid proteome Tissue proteome Mass spectrometry Brain regions Lc-ms/ms 
ProteomicsDiscovery of a testis-specific complex TEX101-DPEP3 and selection of its disrupting antibodies
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa tra...
ORGANISM(S): Homo sapiens (Human) 
2018-08-16 | PXD007515 | Pride
Tex101  testis-expressed sequence 101 protein  dpep3  dipeptidase 3  affinity purification-mass spectrometry  interactome  protein-protein interactions  testis-specific proteins  spermatozoa  disrupting antibodies 
ProteomicsNon-pregnant CVF protome and peptidome
Cervical-vaginal fluid (CVF) covers the lower part of the female reproductive system and functions in the homeostasis and immunity of the surrounding tissues. The proteome of this proximal fluid has mainly been studied in pregnant women, whereas the CVF proteome of non-pregnant women has not been an...
ORGANISM(S): Homo sapiens (Human) 
2017-09-27 | PXD004363 | Pride
Cvf Non-pregnant Lc-ms/ms 
ProteomicsNon-pregnant CVF peptidome - Discovery of Antimicrobial Peptides in Cervical-vaginal Fluid from Healthy Non-pregnant Women Via an Integrated Proteome and Peptidome Analysis
Cervical-vaginal fluid (CVF) covers the lower part of the female reproductive system and functions in the homeostasis and immunity of the surrounding tissues. The proteome of this proximal fluid has mainly been studied in pregnant women, whereas the CVF proteome of non-pregnant women has not been an...
ORGANISM(S): Homo sapiens (Human) 
2017-09-27 | PXD004450 | Pride
Cvf peptidome Lc-ms/ms 
ProteomicsCharacterization of the human urinary proteome and peptidome
Urine represents an ideal source of clinically relevant biomarkers since it contains a large number of proteins and low molecular weight peptides. Characterization of the normal urinary proteome and peptidome can serve as a reference for disease and can aid in biomarker discovery. Proteomic and pept...
ORGANISM(S): Homo sapiens (Human) 
2016-07-12 | PXD003595 | Pride
Human Peptidomics Proteomics Peptide sequence alignment Protease activity analysis Urinary proteome Urinary peptidome Urine Lc-ms/ms 
ProteomicsIdentification of a damaging variant rs35033974 associated with idiopathic male infertility through degradation of TEX101 protein and its transient interactome
Human TEX101 is a testis-specific cell membrane protein expressed exclusively in male germ cells and a validated biomarker of male infertility. TEX101 was suggested to function as a cell surface chaperone of numerous proteins involved in sperm migration and sperm-egg interaction. However, the precis...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD008333 | Pride
A disintegrin and metalloproteinase domain-containing protein 29  interactome  testis-specific proteins  spermatozoa  single nucleotide polymorphism (snp)  deleterious variant  unexplained infertility Tex101  testis-expressed sequence 101 protein  ly6k  lymphocyte antigen 6 complex Locus k  adam29 
ProteomicsMultiplex selected reaction monitoring assay for quantification of 15 human tissue kallikreins in biological samples
Human tissue kallikreins (KLKs) are a group of 15 secreted serine proteases encoded by the largest contiguous cluster of protease genes in the human genome. KLKs are involved in coordination of numerous physiological functions including regulation of blood pressure, neuronal plasticity, skin desquam...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080740 | MassIVE
ProteomicsUrinary PRM analysis of early type 1 diabetes
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis can be captured in the urinary peptidome. We thus examined the urinary peptidomes of otherwise healthy youths with type 1 ...
ORGANISM(S): Homo Sapiens 
2020-01-01 | PXD012389 | panorama
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
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