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UnknownNitazoxanide in Patients Hospitalized With COVID-19 Pneumonia: A Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial.

Background

Nitazoxanide exerts antiviral activity in vitro and in vivo and anti-inflammatory effects, but its impact on patients hospitalized with COVID-19 pneumonia is uncertain.

Methods

A multicentre, randomized, double-blind, placebo-controlled trial was conducted in ...
S-EPMC9043450 | biostudies-literature
UnknownClinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study.

Background

Although dementia has emerged as an important risk factor for severe SARS-CoV-2 infection, results on COVID-19-related complications and mortality are not consistent. We examined the clinical presentations and outcomes of COVID-19 in a multicentre cohort of in-hospital patients, c...
S-EPMC10770897 | biostudies-literature
UnknownPredictors of venous thromboembolism in COVID-19 patients: results of the COVID-19 Brazilian Registry.
Previous studies that assessed risk factors for venous thromboembolism (VTE) in COVID-19 patients have shown inconsistent results. Our aim was to investigate VTE predictors by both logistic regression (LR) and machine learning (ML) approaches, due to their potential complementarity. This cohort stud...
S-EPMC9156830 | biostudies-literature
UnknownAssociation between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress.
ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case-control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patient...
S-EPMC8102547 | biostudies-literature
UnknownPalliative care and COVID-19: acknowledging past mistakes to forge a better future.

Context

COVID-19 induces complex distress across physical, psychological, and social realms and palliative care (PC) has the potential to mitigate this suffering significantly.

Objectives

To describe the clinical characteristics and outcomes of COVID-19 patients with an indication of ...
S-EPMC11306131 | biostudies-literature
UnknownChagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes.
Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecu...
S-EPMC8514447 | biostudies-literature
UnknownHospital characteristics associated with COVID-19 mortality: data from the multicenter cohort Brazilian Registry.
The COVID-19 pandemic caused unprecedented pressure over health care systems worldwide. Hospital-level data that may influence the prognosis in COVID-19 patients still needs to be better investigated. Therefore, this study analyzed regional socioeconomic, hospital, and intensive care units (ICU) cha...
S-EPMC9510333 | biostudies-literature
UnknownPotential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset.
The majority of early prediction scores and methods to predict COVID-19 mortality are bound by methodological flaws and technological limitations (e.g., the use of a single prediction model). Our aim is to provide a thorough comparative study that tackles those methodological issues, considering mul...
S-EPMC9975879 | biostudies-literature
UnknownHypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry.

Background

It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.

Methods

The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospita...
S-EPMC8769529 | biostudies-literature
UnknownABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores.

Objectives

The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in ...
S-EPMC8302820 | biostudies-literature
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