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TranscriptomicsNRASG12V mediates leukemia self renewal [Microarray]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49038 | biostudies-arrayexpress
TranscriptomicsLeukemia stem cell-enriched population expresses self-renewal gene-expression signature [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-63312 | biostudies-arrayexpress
TranscriptomicsNRASG12V mediates self renewal in AML [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49087 | biostudies-arrayexpress
TranscriptomicsNRASG12V mediates leukemia self renewal [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49088 | biostudies-arrayexpress
GenomicsGenome-Wide Analysis of Hypodiploid Acute Lymphoblastic Leukemia

Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive form of leukemia characterized by multiple whole chromosomal losses and very poor outcome. Here we report an integrative genomic analysis that identifies multiple subtypes of hypodiploid ALL characterized by variation in the degree o...

phs000341.v1.p1 | EGA
TranscriptomicsThe Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptio...
ORGANISM(S): Homo sapiens 
2013-01-15 | E-GEOD-27237 | biostudies-arrayexpress
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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