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TranscriptomicsA retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-54924 | biostudies-arrayexpress
GenomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-51558 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [CGH]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-51876 | biostudies-arrayexpress
GenomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [CAP-D3 localization]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-55040 | biostudies-arrayexpress
UnknownWhole-genome analyses resolve early branches in the tree of life of modern birds.
Not available
S-EPMC4405904 | biostudies-literature
UnknownAnalysis of shared heritability in common disorders of the brain.
Not available
S-EPMC6097237 | biostudies-literature
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