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TranscriptomicsTranscriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19490 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling using microarrays to elucidate the effects of partial whiB1 gene deletion in Mycobacterium tuberculosis H37Rv
DNA microarray analysis was performed on RNA from a strain of Mycobacterium tuberculosis H37Rv in which the essential whiB1 gene was deleted from the chromosome but partially complemented by a wild type allele on a plasmid, compared to RNA from H37Rv wild type containing the same plasmid.
ORGANISM(S): Mycobacterium tuberculosis 
2017-12-22 | E-MTAB-5814 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
TranscriptomicsConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
This SuperSeries is composed of the following subset Series: GSE19482: Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS) GSE19490: Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS) GSE19765: Transcriptional responses of human...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19492 | biostudies-arrayexpress
TranscriptomicsRecruitment of Rod Photoreceptors from Short Wavelength Sensitive Cones during the Evolution of Nocturnal Vision in Mammals
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-22 | E-GEOD-74661 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of human dermal macrophages and monocyte-derived macrophages
DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguish...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-60317 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (human data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35457 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-35458 | biostudies-arrayexpress
GenomicsChromatin accessibility profiling of developing cerebellar granule neurons identifies novel neuronal enhancers and reveals a role for Zic transcription factors in neuronal maturation
To identify chromatin mechanisms of neuronal differentiation, we characterized the relationship between chromatin accessibility and gene expression in cerebellar granule neurons (CGNs) of the developing mouse. We used DNase-seq to globally map accessibility of cis-regulatory elements and RNA-seq to ...
ORGANISM(S): Mus musculus 
2015-02-27 | E-GEOD-60731 | biostudies-arrayexpress
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