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TranscriptomicsPeriostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. We report that periostin, a highly expressed cell a...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-21293 | biostudies-arrayexpress
UnknownRegulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.
Not available
S-EPMC3600386 | biostudies-literature
TranscriptomicsNOTCH3 knockdown in non-transformed human esophageal cells
To determine the role of NOTCH3 in human esophageal epitheila homeostasis/squamous cell differentiation Zinc finger E-box binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transition (EMT), senescence an...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27424 | biostudies-arrayexpress
UnknownFbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3.
Not available
S-EPMC7808939 | biostudies-literature
UnknownCNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
Not available
S-EPMC6102046 | biostudies-literature
UnknownEnzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.
Not available
S-EPMC4570879 | biostudies-literature
UnknownCrystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.
Not available
S-EPMC164784 | biostudies-literature
UnknownDeletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
Not available
S-EPMC3077713 | biostudies-literature
UnknownA subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.
Not available
S-EPMC2579884 | biostudies-literature
UnknownAnti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses.
Not available
S-EPMC3766494 | biostudies-literature
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