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Genomicsena-DATASET-VUMC-CCA-26-05-2021-09:58:48:372-433 - samples
Control cohort of lymphoma samples sequenced with a hybrid capture panel designed to be able to detect translocations and mutations in lymphoma samples. used in the paper "Robust detection of translocations in lymphoma FFPE samples using Targeted Locus Capture-based sequencing"
EGAD00001007711 | EGA
GenomicsRobust detection of translocations in lymphoma FFPE samples using Targeted Locus Capture-based sequencing - NGS targeted capture control cohort
In routine diagnostic pathology, cancer biopsies are preserved by Formalin-Fixed, Paraffin-Embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA fragmentation, which compromises sequencing-based analyses of chromosomal rearrangements. Y...
EGAS00001005325 | EGA
TranscriptomicsGene expression analysis in cytoplasmic and nuclear fractions of P493-6 B cells with low c-myc expression to assess long noncoding RNA localization
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59478 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify long noncoding RNAs deregulated in Myc-driven B cell lymphoma
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59479 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Myc-regulated long noncoding RNAs in B cells with variable Myc levels
Myc is a well known transcription factor with important roles in cell cycle, apoptosis and cellular transformation. Long non-coding (lnc)RNAs have recently emerged as a important class of regulatory RNAs. Here, we show that lncRNAs are an extensive component of the Myc-regulated transcriptional prog...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-59477 | biostudies-arrayexpress
TranscriptomicsOverexpression of miR-155 enhances B-cell lymphoma growth by targeting TBRG1
MYC regulates the expression of multiple microRNA (miRNA) genes and defines the Burkitt lymphoma (BL) miRNA signature. Here, we investigate the role of the MYC-regulated miRNAs by gain- and loss-of-function analysis. Overexpression of 5 miRNAs that were significantly downregulated by MYC resulted in...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-64484 | biostudies-arrayexpress
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