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ProteomicsIdentification of cysteine redox states in MTP from PDI-deficient mouse liver
Cysteine redox states in MTP from PDI-deficient mouse liver were determined using differential cysteine alkylation and PRM-MS analysis.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-16 | PXD055650 | Pride
Mtp Differential cysteine alkylation Prm-ms Redox state of cysteines 
ProteomicsOxSWATH applied to the redox characterization of secretomes under oxidative stress conditions
Most of the redox proteomics strategies are focused on the identification and relative quantification of cysteine oxidation changes without considering the variation in the total levels of the proteins. However, the regulation of protein synthesis and protein degradation are also associated with man...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006802 | Pride
Redoxomics  cysteine oxidation  swath-ms  differential alkylation  secretome  dj-1 
ProteomicsOxSWATH applied to in-vitro the characterization of redox state of recombinant DJ-1 proteins
Most of the redox proteomics strategies are focused on the identification and relative quantification of cysteine oxidation changes without considering the variation in the total levels of the proteins. However, the regulation of protein synthesis and protein degradation are also associated with man...
ORGANISM(S): Homo sapiens (Human) 
2019-02-16 | PXD006803 | Pride
Redoxomics  cysteine oxidation  swath-ms  differential alkylation  recombinant dj-1 
ProteomicsHeterogeneous adaptation of cysteine reactivity to a covalent oncometabolite
Metabolism and signaling intersect in the genetic cancer syndrome hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a disease in which mutation of the TCA cycle enzyme fumarate hydratase (FH) causes hyperaccumulation of fumarate. This electrophilic oncometabolite can alter gene activity at...
ORGANISM(S): Homo sapiens (Human) 
2021-05-06 | PXD020073 | Pride
Human Cysteine reactivity Kidney Hlrcc Uok268 
ProteomicsQuantification of sulfenic acid on model protein
Aldolase contains eight free cysteine residues without disulfide formation in its native state, which makes it a suitable model to manipulate the oxidative modifications on cysteine. H2O2 was chosen to treat aldolase since the principle product between which is sulfenic acid.To assess the reduction ...
ORGANISM(S): Lagomorpha Mammalia Gallus gallus (Chicken) 
2016-10-10 | PXD003348 | Pride
Lysozyme Sulfenic acid Aldolase Arsenite 
ProteomicsObtusaquinone is a cysteine modifying compound that targets Keap1 for degradation
Bovine catalase: This is an experiment to use differential cysteine alkylation to map the nature of binding of a cysteine-targeting small molecule OBT (for details of the method, please see the Method Section of the manuscript). The alkylating reagents uses besides the studied drug were iodoacetam...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Homo Sapiens (ncbitaxon:9606) 
2019-11-30 | MSV000084638 | MassIVE
UnknownIdentification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid.
Not available
S-EPMC4401651 | biostudies-literature
UnknownQuantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model.
Not available
S-EPMC3045014 | biostudies-literature
UnknownMetal- and Affinity-Specific Dual Labeling of Cysteine-Rich Proteins for Identification of Metal-Binding Sites.
Not available
S-EPMC7547867 | biostudies-literature
UnknownResidue Adjacency Matrix Based Feature Engineering for Predicting Cysteine Reactivity in Proteins.
Not available
S-EPMC6327741 | biostudies-literature
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